Priority Programme: THYROID TRANS ACT
Translation of Thyroid Hormone Actions beyond Classical Concepts

Publications

• Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.
  Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.
  J Neuroendocrinol. 2018 Mar;30(3):e12573. doi: 10.1111/jne.12573.
  
• Effects of sildenafil treatment on thermogenesis and glucose homeostasis in diet-induced obese mice.
  Johann K, Reis MC, Harder L, Herrmann B, Gachkar S, Mittag J, Oelkrug R.
  Nutr Diabetes. 2018 Mar 13;8(1):9. doi: 10.1038/s41387-018-0026-0.
  
• In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice.
  Harder L, Schanze N, Sarsenbayeva A, Kugel F, Köhrle J, Schomburg L, Mittag J, Hoefig CS.
  Eur Thyroid J. 2018 Jan;7(1):3-12. doi: 10.1159/000481856. Epub 2017 Dec 5.
  
• Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
  Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC.
  Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11323-E11332. doi: 10.1073/pnas.1706801115. Epub 2017 Dec 11. PMID: 29229863.
  
• A century of thyroid hormone research - Vol. II : Evolution and Development of the Thyroid System
  Edited by Robert Opitz and Josef Köhrle
  Molecular and Cellular Endocrinology, Volume 459, Pages 1-116 (25 December 2017).
  
• A century of thyroid hormone research - Vol. I: The expanded thyroid hormone network: novel metabolites and modes of action
  Edited by Josef Köhrle and Carolin S. Höfig
  Molecular and Cellular Endocrinology, Volume 458, Pages 1-168 (15 December 2017).
  
• Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.
  Zieger K, Weiner J, Kunath A, Gericke M, Krause K, Kern M, Stumvoll M, Klöting N, Blüher M, Heiker JT.
  Cell Mol Life Sci. 2017 Sep 20. doi: 10.1007/s00018-017-2658-y. [Epub ahead of print]. PMID:28932870.
  
• 3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?
  Khajavi N, Mergler S, Biebermann H.
  Front Endocrinol (Lausanne). 2017 Aug 16;8:198. doi: 10.3389/fendo.2017.00198. eCollection 2017.
  
• Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
  Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M.
  Nature Communications 8, Article number: 484 (2017). doi:10.1038/s41467-017-00604-6
  
• Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy
  Oelkrug R, Herrmann B, Geissler C, Harder L, Koch C, Lehnert H, Oster H, Kirchner H, Mittag J.
  Molecular Metabolism 2017, DOI: http://dx.doi.org/10.1016/j.molmet.2017.06.016
  
• Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway.
  Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, Blüher M, Heiker JT.
  Mol Cell Endocrinol. 2017 Jul 26. pii: S0303-7207(17)30395-7. doi: 10.1016/j.mce.2017.07.022. [Epub ahead of print]
  
• Differential Regulation of Monocarboxylate Transporter 8 Expression in Thyroid Cancer and Hyperthyroidism.
  Badziong J, Ting S, Synoracki S, Tiedje V, Brix K, Brabant G, Moeller LC, Schmid KW, Führer-Sakel D, Zwanziger D.
  Eur J Endocrinol. 2017 Jun 2. pii: EJE-17-0279. doi: 10.1530/EJE-17-0279. [Epub ahead of print] PMID:28576880
  
• Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.
  Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley RA, Gygi SP, Stoedter M, Wisniewska M, Köhrle J, Gladyshev VN, Schomburg L.
  Sci Rep. 2017 Jun 29;7(1):4391. doi: 10.1038/s41598-017-04586-9. PMID:28663583.
  
• Membrane traversing mechanism for thyroid hormone transport at MCT8
  Protze J, Braun D, Hinz KM, Bayer-Kusch D, Schweizer U, Krause G.
  Cell Mol Life Sci, 2017 Jun;74(12):2299-2318. doi: 10.1007/s00018-017-2461-9. Epub 2017 Jan 28
  
• Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.
  Kleinau G, Worth CL, Kreuchwig A, Biebermann H, Marcinkowski P, Scheerer P, Krause G.
  Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017.
  
• TRH action is impaired in pituitaries of male IGSF1-deficient mice
  Turgeon M-O, Silander TL, Doycheva D, Liao X-H, Rigden M, Ongaro L, Zhou X, Joustra SD, Wit JM, Wade MG, Heuer H, Refetoff S, Bernard DJ.
  Endocrinology, Endocrine Society, Submitted: October 24, 2016 Accepted: January 06, 2017, First Online: January 13, 2017. DOI: 10.1210/en.2016-1788
  
• Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation.
  Weiner J, Rohde K, Krause K, Zieger K, Klöting N, Kralisch S, Kovacs P, Stumvoll M, Blüher M, Böttcher Y, Heiker JT.
  Mol Metab. 2017 Mar 28;6(6):482-493. doi: 10.1016/j.molmet.2017.03.004. eCollection 2017 Jun.
  
• Copper to Zinc Ratio as Disease Biomarker in Neonates with Early-Onset Congenital Infections.
  Wisniewska M, Cremer M, Wiehe L, Becker NP, Rijntjes E, Martitz J, Renko K, Bührer C, Schomburg L.
  Nutrients. 2017 Mar 30;9(4). pii: E343. doi: 10.3390/nu9040343. PMID:28358335.
  
• 3-Iodothyronamine induces tail vasodilation through central action in male mice
  Gachkar S, Oelkrug R, Martinez-Sanchez N, Rial-Pensado E, Warner A, Hoefig CS, López M, Mittag J.
  Endocrinology en.2016-1951. DOI: https://doi.org/10.1210/en.2016-1951 Published: 23 March 2017
  
• Thyroid hormone transport across L-type amino acid transporters: What can molecular modelling tell us?
  Krause G, Hinz KM.
  Mol Cell Endocrinology, 2017, March 21 pii: S0303-7207(17)30189-2 doi: 10.1016/j.mce.2017.03.018
  
• Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids
  Hinz KM, Neef D, Rutz C, Furkert J, Koehrle J, Schuelein R, Krause G.
  Mol Cell Endocrinology Mar 5;443:163-174. doi: 10.1016/j.mce.2017.01.024
  
• Avoiding the pitfalls when quantifying thyroid hormones and their metabolites using mass spectrometric methods: The role of quality assurance.
  Richards K, Rijntjes E, Rathmann D, Köhrle J.
  Mol Cell Endocrinol. 2017 Jan 31. pii: S0303-7207(17)30046-1. doi: 10.1016/j.mce.2017.01.032. [Epub ahead of print] Review. PMID: 28153800.
  
• Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model
  Pietzner M, Engelmann B, Kacprowski T, Golchert J, Dirk A-L, Hammer E, Iwen K.A., Nauck M, Wallaschofski H, Führer D, Münte T.F., Friedrich N, Völker U, Homuth G, Brabant G.
  BMC Med. 2017; 15: 6., Published online 2017 Jan 9. doi: 10.1186/s12916-016-0770-8. PMCID: PMC5220622.
  
• Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P.
  Hybsier S, Schulz T, Wu Z, Demuth I, Minich WB, Renko K, Rijntjes E, Köhrle J, Strasburger CJ, Steinhagen-Thiessen E, Schomburg L.
  Redox Biol. 2017 Apr;11:403-414. doi: 10.1016/j.redox.2016.12.025. Epub 2016 Dec 29. PMID:28064116.
  
• Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study
  Langouche L, Lehmphul I, Vander Perre S, Köhrle J, Van den Berghe G.
  Thyroid. Dec 2016, 26(12): 1674-1680.
  
• A Nonradioactive DEHAL Assay for Testing Substrates, Inhibitors, and Monitoring Endogenous Activity.
  Renko K, Hoefig CS, Dupuy C, Harder L, Schwiebert C, Köhrle J, Schomburg L.
  Endocrinology. 2016 Dec;157(12):4516-4525. Epub 2016 Oct 12. PMID: 27732086.
  
• Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
  Weiner J, Kranz M, Klöting N, Kunath A, Steinhoff K, Rijntjes E, Köhrle J, Zeisig V, Hankir M, Gebhardt C, Deuther-Conrad W, Heiker JT, Kralisch S, Stumvoll M, Blüher M, Sabri O, Hesse S, Brust P, Tönjes A, Krause K.
  Scientific Reports | 6:38124 | DOI: 10.1038/srep38124, Published: 12 December 2016
  
• Thyroid hormone and its metabolites in relation to quality of life in patients treated for differentiated thyroid cancer.
  Massolt ET, van der Windt M, Korevaar TI, Kam BL, Burger JW, Franssen GJ, Lehmphul I, Köhrle J, Visser WE, Peeters RP.
  Clin Endocrinol (Oxf). 2016 Nov;85(5):781-788. doi: 10.1111/cen.13101.PMID:27175823.
  
• 3-Iodothyronamine decreases expression of genes involved in iodide metabolism in mouse thyroids and inhibits iodide uptake in PCCL3 thyrocytes
  Schanze N, Jacobi SF, Rijntjes E, Mergler S, del Olmo M, Hoefig CS, Khajavi N, Lehmphul I, Biebermann H, Mittag J, Köhrle J.
  Thyroid. 2017 Jan;27(1):11-22. doi: 10.1089/thy.2016.0182. Epub 2016 Dec 21.
  
• Efficacy of protocols for induction of chronic hyperthyroidism in male and female mice.
  Engels K, Rakov H, Zwanziger D, Hönes GS, Rehders M, Brix K, Köhrle J, Möller LC, Führer D.
  Endocrine. 2016 Oct;54(1):47-54. PMID:27473100.
  
• Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
  Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.
  Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. PMID:27720451
  
• Thyronamines and derivatives: Physiological relevance, pharmacological actions and future research directions.
  Hoefig CS, Zucchi R, Koehrle J.
  Thyroid. 2016 Dec;26(12):1656-1673. Epub 2016 Nov 9. PMID: 27650974.
  
• Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice.
  Rakov H, Engels K, Hönes GS, Strucksberg KH, Moeller LC, Köhrle J, Zwanziger D, Führer D.
  Biol Sex Differ. 2016 Aug 24;7(1):36. doi: 10.1186/s13293-016-0089-3. PMID:27559466.
  
• Selenium status in neonates with connatal infection.
  Wiehe L, Cremer M, Wisniewska M, Becker NP, Rijntjes E, Martitz J, Hybsier S, Renko K, Bührer C, Schomburg L.
  Br J Nutr. 2016 Aug;116(3):504-13. doi: 10.1017/S0007114516002208. Epub 2016 Jun 8.
  
• Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10.
  Johannes J, Braun D, Kinne A, Rathmann D, Köhrle J, Schweizer U.
  Mol Endocrinol. 2016 Jul;30(7):796-808. doi: 10.1210/me.2016-1037. PMID:27244477
  
• The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.
  Zwanziger D, Schmidt M, Fischer J, Kleinau G, Braun D, Schweizer U, Moeller LC, Biebermann H, Fuehrer D.
  Mol Cell Endocrinol. 2016 May 21. pii: S0303-7207(16)30175-7. doi: 10.1016/j.mce.2016.05.017. [Epub ahead of print]. PMID: 27222294
  
• Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice.
  Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J.
  Endocrinology. 2016 May 4:en20161095. [Epub ahead of print]
  
• Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men.
  Beukhof CM, Medici M, van den Beld AW, Hollenbach B, Hoeg A, Visser WE, de Herder WW, Visser TJ, Schomburg L, Peeters RP.
  PLoS One. 2016 Apr 7;11(4):e0152748. doi: 10.1371/journal.pone.0152748. eCollection 2016.PMID:27055238.
  
• Efficient activation of pathogenic Phe501 mutation in monocarboxylate transporter 8 by chemical and pharmacological chaperones
  Braun D, Schweizer U.
  Endocrinology 2015 Dec 14;156(12):4720-30. Epub 2015 Sep 14.
  
• Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones.
  Mondal S, Raja K, Schweizer U, Mugesh G.
  Angew Chem Int Ed Engl. 2016 Jun 27;55(27):7606-30. doi: 10.1002/anie.201601116. Epub 2016 May 25.
  
• Biosynthesis of 3-Iodothyronamine From T4 in Murine Intestinal Tissue.
  Hoefig CS, Wuensch T, Rijntjes E, Lehmphul I, Daniel H, Schweizer U, Mittag J, Köhrle J.
  Endocrinology. 2015 Nov;156(11):4356-64. doi: 10.1210/en.2014-1499. Epub 2015 Sep 8. PMID:26348473 [PubMed - indexed for MEDLINE]
  
• Association of antiepileptic drug usage, trace elements and thyroid hormone status.
  Zevenbergen C, Korevaar TI, Schuette A, Peeters RP, Medici M, Visser TJ, Schomburg L, Visser WE.
  Eur J Endocrinol. 2016 Apr;174(4):425-32. doi: 10.1530/EJE-15-1081. Epub 2015 Dec 23. PMID:26701870.
  
• Silychristin, a flavonolignan derived from the milk thistle is a potent inhibitor of the thyroid hormone transporter MCT8
  Johannes J, Jayarama-Naidu R, Meyer F, Wirth EK, Schweizer U, Schomburg L, Köhrle J, Renko K.
  Endocrinology. 2016 Apr;157(4):1694-701. doi: 10.1210/en.2015-1933. Epub 2016 Feb 24. PMID: 26910310.
  
• High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population.
  Ittermann T, Lorbeer R, Dörr M, Schneider T, Quadrat A, Heßelbarth L, Wenzel M, Lehmphul I, Köhrle J, Mensel B, Völzke H.
  Eur Radiol. 2016 Mar 14. [Epub ahead of print]. PMID: 26973144 [PubMed - as supplied by publisher]
  
• 3,5-T2 alters murine genes relevant for xenobiotic, steroid and thyroid hormone metabolism.
  Lietzow J, Golchert J, Homuth G, Völker U, Jonas W, Köhrle J.
  J Mol Endocrinol. 2016 Feb 22. pii: JME-15-0159 [Epub ahead of print]. PMID:26903510 [PubMed - as supplied by publisher]
  
• A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2A.
  Latteyer S, Klein-Hitpass L, Khandanpour C, Zwanziger D, Poeppel TD, Schmid KW, Führer D, Moeller LC.
  J Clin Endocrinol Metab. 2016 Mar;101(3):1016-22. doi: 10.1210/jc.2015-2948. Epub 2016 Jan 14. PMID:26765577 [PubMed - in process]
  
• Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves' Ophthalmopathy.
  Dehina N, Hofmann PJ, Behrends T, Eckstein A, Schomburg L.
  Eur Thyroid J. 2016 Mar;5(1):57-64. doi: 10.1159/000442440. Epub 2016 Jan 16. PMID:27099840.
  
• New insights into the structure and mechanism of iodothyronine deiodinases.
  Schweizer U, Steegborn C.
  J Mol Endocrinol. 2015 Dec;55(3):R37-52. doi: 10.1530/JME-15-0156. Epub 2015 Sep 21. PMID: 26390881 [PubMed - in process]
  
• Thyroid hormones-From Crystal Packing to Activity to Reactivity.
  Schweizer U, Steegborn C.
  Angew Chem Int Ed Engl. 2015 Oct 26;54(44):12856-8. doi: 10.1002/anie.201506919. Epub 2015 Sep 11. PMID: 26358899 [PubMed - in process]
  
• Transport of Iodothyronines by human L-Type Amino Acid Transporters
  Zevenbergen C, Meima ME, Peeters RP, Kinne A, Krause G, Visser WE, Visser TJ.
  Endocrinology 2015 Nov;156(11):4345-55.en20151140. [Epub ahead of print]
  
• Gene-specific regulation of hepatic selenoprotein expression by interleukin-6.
  Martitz J, Becker NP, Renko K, Stoedter M, Hybsier S, Schomburg L.
  Metallomics. 2015 Nov;7(11):1515-21. doi: 10.1039/c5mt00211g. Epub 2015 Sep 23.PMID:26399395.
  
• Distinct urinary metabolic profiles associated with serum TSH and FT4 concentrations
  Pietzner M, Budde K, Homuth G, Völker U, Völzke H, Nauck M, Wallaschofski H, Friedrich N.
  Metabolomics, October 2015, Volume 11, Issue 5, pp 1316–1326.
  
• Interaction of thyroid hormone with brown adipose tissue. Lessons learned from PET-CT.
  Steinhoff KG, Hankir M , Krause K, Tönjes A, Fenske WK, Sabri O, Hesse S.
  Nuklearmedizin. 2015 Jun 23;54(3):82-7; PMID: 26105715 [PubMed - in process]
  
• Understanding the healthy thyroid state in 2015
  Führer D, Brix K, Biebermann H.
  Eur Thyroid J 2015;4(suppl 1):1-8 (DOI:10.1159/000431318)
  
• Evolutionary conservation of 3-iodothyronamine as agonist at the trace amine-associated receptor 1
  Cöster M, Biebermann H, Schöneberg T, Stäubert C.
  Eur Thyroid J 2015;4(suppl 1):9-20 (DOI:10.1159/000430839)
  
• Trace amine-associated receptor 1 localization at the apical plasma membrane domain of Fisher rat thyroid epithelial cells is confined to cilia
  Szumska J, Qatato M, Rehders M, Führer D, Biebermann H, Grandy DK, Köhrle J, Brix K.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):30-41. doi: 10.1159/000434717. Epub 2015 Jun 10. PMID: 26601071 [PubMed]
  
• Quantitative analysis of thyroid hormone metabolites in cell culture samples using LC MS/MS
  Rathmann D, Rijntjes E, Lietzow J, Köhrle J.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):51-8. doi: 10.1159/000430840. Epub 2015 May 28. PMID: 26601073 [PubMed]
  
• The effects of thyroid hormones on gene expression of acyl-coenzyme A thioesterases in adipose tissue and liver of mice
  Krause K, Weiner J, Hönes S, Klöting N, Rijntjes E, Gebhardt C, Heiker JT, Köhrle J, Führer D, Steinhoff K, Hesse S, Moeller LC, Tönjes, A.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):59-66. doi: 10.1159/000437304. Epub 2015 Jul 2. PMID: 26601074 [PubMed]
  
• Establishment of an effective radioiodide thyroid ablation protocol in mice
  Schmohl KA, Müller AM, Schwenk N, Knoop K, Rijntjes E, Köhrle J, Heuer H, Bartenstein P, Göke B, Nelson PJ, Spitzweg C.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):74-80. doi: 10.1159/000381019. Epub 2015 May 23. PMID: 26601076 [PubMed]
  
• Differences in mouse hepatic thyroid hormone transporter expression with age and hyperthyroidism
  Engels K, Rakov H, Zwanziger D, Moeller LC, Homuth G, Koehrle J, Brix K, Fuhrer D.
  Eur Thyroid J 2015;4(suppl 1):81-86 (DOI:10.1159/000381020)
  
• High T3, low T4 serum levels in Mct8-deficiency are not caused by increased hepatic conversion through type I-deiodinase
  Wirth EK, Rijntjes E, Meyer F, Köhrle J, Schweizer U.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):87-91. doi: 10.1159/000381021. Epub 2015 May 23. PMID: 26601078 [PubMed]
  
• Urine metabolomics by 1H-NMR spectroscopy indicates associations between serum 3,5-T2 concentrations and intermediary metabolism in euthyroid humans
  Pietzner M, Homuth G, Budde K, Lehmphul I, Völker U, Völzke H, Nauck M, Köhrle J, Friedrich N.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):92-100. doi: 10.1159/000381308. Epub 2015 May 28. PMID: 26601079 [PubMed]
  
• Serum Thyrotropin Concentrations are not Associated with the Ankle-Brachial Index – Results from Three Population-Based Studies
  Ittermann T, Lorbeer R, Tiller D, Lehmphul I, Kluttig A, SB Felix, Werdan K, Greiser KH, Köhrle J, Völzke H, Dörr M.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):101-7. doi: 10.1159/000381309. Epub 2015 May 27. PMID: 26601080 [PubMed]
  
• Two novel mutations in the Serpina7 gene are associated with complete deficiency of thyroxine-binding globulin
  Moeller LC, Appiagyei-Dankah Y, Köhler B, Biebermann H, Janßen OE, Führer D.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):108-12. doi: 10.1159/000381093. Epub 2015 May 30. PMID: 26601081 [PubMed]
  
• Effect of experimental thyrotoxicosis onto blood coagulation – A proteomics study
  Engelmann B, Bischof J, Dirk, AL, Friedrich N, Hammer E Thiele T, Führer D, Homuth G, Brabant G, Völker U.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):119-24. doi: 10.1159/000381769. Epub 2015 May 28. PMID: 26601083 [PubMed]
  
• Sex-dependent claudin-1 expression in liver of eu- and hypothyroid mice
  Zwanziger D, Rakov H, Engels K, Moeller LC, Fuhrer D.
  Eur Thyroid J 2015;4(suppl 1):67-73 (DOI:10.1159/000431316)
  
• A nonradioactive uptake assay for rapid analysis of thyroid hormone transporter function.
  Jayarama-Naidu R, Johannes J, Meyer F, Wirth EK, Schomburg L, Köhrle J, Renko K.
  Endocrinology. 2015 Jul;156(7):2739-45. doi: 10.1210/en.2015-1016. Epub 2015 Apr 24. PMID: 25910050 [PubMed - indexed for MEDLINE]
  
• An improved non-radioactive screening method identifies genistein and xanthohumol as potent inhibitors of iodothyronine deiodinases.
  Renko K, Schäche S, Hoefig CS, Welsink T, Schwiebert C, Braun D, Becker NP, Koehrle J, Schomburg L.
  Thyroid. 2015 Aug;25(8):962-8. doi: 10.1089/thy.2015.0058. Epub 2015 Jun 25. PMID: 25962824 [PubMed - in process]
  
• The multi-target ligand 3-iodothyronamine modulates beta-adrenergic receptor 2 signaling.
  Dinter J, Khajavi N, Mühlhaus J, Wienchol CL, Cöster M, Hermsdorf T, Stäubert C, Köhrle J, Schöneberg T, Kleinau G, Mergler S, Biebermann H.
  Eur Thyroid J 2015;4(suppl 1):21-29 (DOI:10.1159/000381801)
  
• Structural insights into thyroid hormone transport mechanisms of the L-amino acid transporter 2
  Hinz KM, Meyer K, Kinne A, Schülein R, Köhrle J, Krause G.
  MolEndocrinology, May 2015 [Epub ahead of print]. Received: February 04, 2015. Accepted: May 01, 2015. First Published Online: May 06, 2015.
  
• Involvement of the L-type amino acid transporter Lat2 in the transport of 3.3`diio-dothyronines across the plasma membrane
  Kinne A, Wittner M, Wirth EK, Hinz KM, Schülein R, Köhrle J, Krause G.
  Eur Thyroid J. 2015 Sep; 4(Suppl 1): 42–50. Published online 2015 May 28. doi: 10.1159/000381542. PMCID: PMC4640293
  
• Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth.
  Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H.
  J Clin Endocrinol Metab. 2015 May;100(5):2090-7. doi: 10.1210/jc.2014-4466. Epub 2015 Mar 17. PMID: 25781359 [PubMed - indexed for MEDLINE]
  
• 3-iodothyronamine differentially modulates alpha-2A adrenergic receptor-mediated signaling.
  Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Höfig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.
  J Mol Endocrinol. 2015 Apr 15. pii: JME-15-0003. [Epub ahead of print] PMID: 25878061
  
• Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
  Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H.
  PLoS One. 2015 Feb 23;10(2):e0117774. doi: 10.1371/journal.pone.0117774. eCollection 2015.
  
• Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds.
  Stoedter M, Renko K, Ibáñez E, Plano D, Becker NP, Martitz J, Palop JA, Calvo A, Sanmartín C, Schomburg L.
  Metallomics. 2015 Feb 11;7(2):347-54. doi: 10.1039/c4mt00273c.PMID: 25579002[PubMed - in process]
  
• Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.
  Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.
  J Mol Endocrinol. 2015 Feb;54(1):39-50. doi: 10.1530/JME-14-0272. PMID: 25527620
  
• Absence of TRH-receptor 1 in male mice affects gastric ghrelin production
  Mayerl S, Liebsch C, Visser TJ, Heuer H.
  Endocrinology. doi: 10.1210/en.2014-1395. Received: May 15, 2014. Accepted: December 04, 2014. Published Online: December 09, 2014
  
• Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells
  Khajavi N, Reinach PS, Slavi N, Skrzypski M, Lucius A, Strauß O, Köhrle J, Mergler S.
  Cellular Signalling, Volume 27, Issue 2, February 2015, Pages 315–325. doi:10.1016/j.cellsig.2014.11.015. Received: 16 September 2014. Received in revised form: 31 October 2014. Accepted: 12 November 2014. Available online: 21 November 2014
  
• [SPP-related publication] In Vitro and Mouse Studies Supporting Therapeutic Utility of Triiodothyroacetic Acid in MCT8 Deficiency.
  Kersseboom S, Horn S, Visser WE, Chen J, Friesema EC, Vaurs-Barrière C, Peeters RP, Heuer H, Visser TJ.
  Mol Endocrinol. 2014 Nov 12:me20141135. [Epub ahead of print] doi: 10.1210/me.2014-1135
  
• Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile
  Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Chun-Xia Yi, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H.
  Int. J. Mol. Sci. 2014, 15, 20638-20655. doi:10.3390/ijms151120638. Received: 3 August 2014; in revised form: 25 October 2014. Accepted: 4 November 2014. Published: 10 November 2014
  
• Translating pharmacological findings from hypothyroid rodents to euthyroid humans: Is there a functional role of endogenous 3,5-T2?
  Pietzner M, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R, Völker U, Brabant G, Völzke H, Koehrle J, Homuth G, Wallaschofski H.
  doi:10.1089/thy.2014.0262 Thyroid. 2014 Oct 24. [Epub ahead of print]
  
• 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male dietinduced obese mice.
  Jonas W, Lietzow J, Wohlgemuth F, Hoefig CS, Wiedmer P, Schweizer U, Köhrle J, Schürmann A.
  Endocrinology. 2014 Oct 16:en20141604. [Epub ahead of print] PMID:25322465
  
• High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population.
  Ittermann T, Dörr M, Völzke H, Tost F, Lehmphul I, Köhrle J, Jürgens C.
  Thyroid. 2014 Oct;24(10):1473-8. doi: 10.1089/thy.2014.0190. PMID:25156414 [PubMed - in process]
  
• Constitutive activities in the thyrotropin receptor: regulation and significance
  Kleinau G, Biebermann H.
  Adv Pharmacol. 2014;70:81-119. doi:10.1016/B978-0-12-417197-8.00003-1. PMID:24931193 [PubMed - in process]
  
• Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets.
  Spitzweg C, Bible KC, Hofbauer LC, Morris JC.
  Lancet Diabetes Endocrinol. 2014 Oct;2(10):830-42. doi: 10.1016/S2213-8587(14)70051-8. Epub 2014 Jun 2. PMID:24898835 [PubMed - in process]
  
• Structure and Function of Thyroid Hormone Plasma Membrane Transporters
  Schweizer U, Johannes J, Bayer D, Braun D.
  Published online: September 10, 2014, Eur Thyroid J 2014;3:143-153. doi:10.1159/000367858
  
• Serum thyroid-stimulating hormone levels are not associated with exercise capacity and lung function parameters in two population-based studies.
  Ittermann T, Gläser S, Ewert R, Felix S, Völzke H, Dörr M.
  BMC Pulm Med. 2014 Sep 2;14:145. doi: 10.1186/1471-2466-14-145. PMID:25182209 [PubMed - in process]
  
• Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody-based chemiluminescence immunoassay.
  Lehmphul I, Brabant G, Wallaschofski H, Ruchala M, Strasburger CJ, Köhrle J, Wu Z.
  Thyroid. 2014 Sep;24(9):1350-60. doi: 10.1089/thy.2013.0688. Epub 2014 Aug 1. PMID:24967815
  
• Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.
  Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE.
  Int J Cancer. 2015 Mar 1;136(5):1149-61. doi: 10.1002/ijc.29071. Epub 2014 Jul 21.
  
• Transport of thyroid hormone in brain.
  Wirth EK, Schweizer U, Köhrle J.
  Front Endocrinol (Lausanne). 2014 Jun 24;5:98. doi: 10.3389/fendo.2014.00098. eCollection 2014. Review. PMID:25009532 [PubMed]
  
• Expression pattern of thyroid hormone transporters in the postnatal mouse brain
  Müller J, Heuer H.
  Front. Endocrinol., 18 June 2014 | doi: 10.3389/fendo.2014.00092
  
• [SPP-related publication] - Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
  Schweizer U, Schlicker C, Braun D, Köhrle J, Steegbornd C.
  Published online before print July 7, 2014, doi:10.1073/pnas.1323873111 PNAS July 7, 2014
  
• Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors.
  Illouz F, Braun D, Briet C, Schweizer U, Rodien P.
  Eur J Endocrinol. 2014 Sep;171(3):R91-9. doi: 10.1530/EJE-14-0198. Epub 2014 May 15. Review.
  
• Selenoprotein P is the essential selenium transporter for bones.
  Pietschmann N, Rijntjes E, Hoeg A, Stoedter M, Schweizer U, Seemann P, Schomburg L.
  Metallomics. 2014 May;6(5):1043-9. doi: 10.1039/c4mt00003j.PMID: 24626785 [PubMed - indexed for MEDLINE]
  
• Hypoxia reduces and redirects selenoprotein biosynthesis.
  Becker NP, Martitz J, Renko K, Stoedter M, Hybsier S, Cramer T, Schomburg L.
  Metallomics. 2014 May;6(5):1079-86. doi: 10.1039/c4mt00004h. PMID: 24700164 [PubMed - indexed for MEDLINE]
  
• Soy isoflavones interfere with thyroid hormone homeostasis in orchidectomized middle-aged rats.
  Šošić-Jurjević B, Filipović B, Wirth EK, Živanović J, Radulović N, Janković S, Milošević V, Köhrle J.
  Toxicol Appl Pharmacol. 2014 Jul 15;278(2):124-34. doi: 10.1016/j.taap.2014.04.018. Epub 2014 Apr 29.
  
• Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
  Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H.
  J Clin Invest. 2014 May 1;124(5):1987-99. Epub 2014 Apr 1. [PMID:24691440]
  
• [Thyroid hormone action beyond classical concepts. The priority programme "Thyroid Trans Act" (SPP 1629) of the German Research Foundation]
  Führer D, Brix K, Biebermann H.
  Dtsch Med Wochenschr. 2014 Mar;139(10):492-6. doi: 10.1055/s-0034-1369822. Epub 2014 Feb 25. Review. German.
  
• Authentic Bosutinib Inhibits T3-Transport by Monocarboxylate Transporter 8 (MCT8).
  Braun D, Schweizer U.
  Thyroid. 2014 Jan 30. Epub ahead of print. [PMID:24479416]
  
• Tissue-Specific Alterations in Thyroid Hormone Homeostasis in Combined Mct10 and Mct8 Deficiency.
  Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H.
  Endocrinology. 2014 Jan;155(1):315-25. doi: 10.1210/en.2013-1800. Epub 2013 Dec 20. [PMID: 24248460]
  
• EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene.
  Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C.
  Mol Ther Nucleic Acids. 2013 Nov 5;2:e131. doi: 10.1038/mtna.2013.58. PMID:24193032 [PubMed] PMCID:PMC3889187
  
• Sex-specific associations between thyrotropin and serum lipid profiles.
  Meisinger C, Ittermann T, Tiller D, Agger C, Nauck M, Schipf S, Wallaschofski H, Jørgensen T, Linneberg A, Thiery J, Kluttig A, Greiser H, Werdan K, Burkhardt K, Völzke H.
  Thyroid. 2014 Mar;24(3):424-32. doi: 10.1089/thy.2013.0259. Epub 2013 Nov 14. [PMID: 24102572]
  
• Research resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses.
  Kreuchwig A, Kleinau G, Krause G.
  Mol Endocrinol. 2013 Aug;27(8):1357-63. doi: 10.1210/me.2013-1115. Epub 2013 Jun 24. [PMID:23798574]
  
• Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies.
  Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, Köhrle J, Wiersinga WM.
  Clin Endocrinol (Oxf). 2014 Mar;80(3):444-51. doi: 10.1111/cen.12284. Epub 2013 Jul 31.
  
• The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
  Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.
  Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. [PMID: 23744028]
  
• Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.
  Piechowski CL, Rediger A, Lagemann C, Mühlhaus J, Müller A, Pratzka J, Tarnow P, Grüters A, Krude H, Kleinau G, Biebermann H.
  Journal of molecular endocrinology 51:109-118. Accepted Preprint (first posted online 14 May 2013)
  
• Novel insights on thyroid-stimulating hormone receptor signal transduction.
  Kleinau G, Neumann S, Grüters A, Krude H, Biebermann H.
  Endocr Rev. 2013 Oct;34(5):691-724. doi: 10.1210/er.2012-1072. [PMID: 23645907]
  
• Histidines in Potential Substrate Recognition Sites Affect Thyroid Hormone Transport by Monocarboxylate Transporter 8 (MCT8).
  Braun D, Lelios I, Krause G, Schweizer U.
  Endocrinology. 2013 Jul;154(7):2553-61. doi: 10.1210/en.2012-2197. Epub 2013 Apr 16. [PMID: 23592749]
  
• Determinants Involved in Subtype-specific Functions of Rat Trace Amine-associated Receptors 1 and 4.
  Stäubert C, Bohnekamp J, Schöneberg T.
  Br J Pharmacol. 2013 Mar;168(5):1266-78. doi:10.1111/bph.12020. [PMID:23072560]
  
• Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.
  Hoyer I, Haas AK, Kreuchwig A, Schülein R, Krause G.
  Biochem Soc Trans. 2013 Feb 1;41(1):213-7.doi:0.1042/BST20120319. [PMID:23356285], [PMCID:PMC3561627]