Priority Programme: THYROID TRANS ACT
Translation of Thyroid Hormone Actions beyond Classical Concepts

Publications

• Noncanonical Action of Thyroid Hormone Receptors α and β
  Hönes GS, Geist D, Moeller LC
  Exp Clin Endocrinol Diabetes. 2020 Apr 24. doi: 10.1055/a-1088-1187
  
• CD5L constitutes a novel biomarker for integrated hepatic thyroid hormone action.
  Nock S, Johann K, Harder L, Wirth EK, Renko K, Höfig C, Kracke V, Hackler J, Engelmann B, Rauner M, Köhrle J, Schomburg L, Homuth G, Völker U, Brabant G, Mittag J.
  Thyroid. 2020 Mar 18. doi: 10.1089/thy.2019.0635
  
• More Than Fever - Novel Concepts in the Regulation of Body Temperature by Thyroid Hormones.
  Mittag J.
  Exp Clin Endocrinol Diabetes. 2019 Oct 25. doi: 10.1055/a-1014-2510
  
• Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers.
  Nock S, Höfig C, Harder L, Schomburg L, Brabant G, Mittag J.
  Exp Clin Endocrinol Diabetes. 2019 Oct 7. doi: 10.1055/a-1012-8484
  
• Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses
  Kerp H, Gassen J, Führer D.
  Exp Clin Endocrinol Diabetes. 2020 Jan 13. doi: 10.1055/a-1083-6272.
  
• Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland
  Dauth S, Rakov H, Sîrbulescu RF, Ilieş I, Weber J, Batbajar Dugershaw B, Braun D, Rehders M, Wirth EK, Führer D, Schweizer U, Brix K.
  Cell Mol Neurobiol. 2019 Dec 5. doi: 10.1007/s10571-019-00765-6
  
• Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling
  Mayerl S, Heuer H, Ffrench-Constant C.
  Stem Cell Reports. 2020 April 16, DOI: 10.1016/j.stemcr.2020.03.014
  
• Age effect on thyroid hormone brain response in male mice.
  Kerp H, Engels K, Kramer F, Doycheva D, Hönes GS, Zwanziger D, Moeller LC, Heuer H, Fuehrer D.
  Endocrine. 2019 Dec;66(3):596-606
  
• A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans.
  Pietzner M, Köhrle J, Lehmphul I, Budde K, Kastenmüller G, Brabant G, Völzke H, Artati A, Adamski J, Völker U, Nauck M, Friedrich N, Homuth G.
  Thyroid, 2019 Dec;29(12):1743-1754.
  
• Thyroid hormone transporters
  Groeneweg S, van Geest FS, Peeters RP, Heuer H, Visser WE.
  Endocr Rev. 2020 Apr 1;41(2). doi: 10.1210/endrev/bnz008.
  
• Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone Induced Cardiac Hypertrophy and Pyrexia.
  Herrmann B, Harder L, Oelkrug R, Chen J, Gachkar S, Nock S, Resch J, Korkowski M, Heuer H, Mittag J.
  Thyroid. 2020 Mar 18; [Epub ahead of print]
  
• Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression
  Wilpert NM, Krueger M, Opitz R, Sebinger D, Paisdzior S, Mages B, Schulz A, Spranger J, Wirth EK, Stachelscheid H, Mergenthaler P, Vajkoczy P, Krude H, Kühnen P, Bechmann I, Biebermann H.
  Thyroid. 2020 Mar 6. doi: 10.1089/thy.2019.0544
  
• Allan-Herndon-Dudley-Syndrome: Considerations about the Brain Phenotype with Implications for Treatment Strategies.
  Krude H, Biebermann H, Schuelke M, Müller TD, Tschöp M.
  Exp Clin Endocrinol Diabetes. 2020 Apr 2. doi: 10.1055/a-1108-1456.
  
• N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice.
  Gachkar S, Oelkrug R, Herrmann B, Scanlan TS, Sun Q, Biebermann H, Hoefig CS, Schomburg L, Mittag J.
  Eur Thyroid J. 2020 Feb;9(2):57-66. doi: 10.1159/000504887
  
• 3,5-T2 – A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine And Intracrine Hepatic Action.
  Köhrle J, Lehmphul I, Pietzner M, Renko K, Rijntjes E, Richards K, Anselmo J, Danielsen M, Jonklaas J.
  Frontiers in Endocrinology, Thyroid Endocrinology.
  
• Lack of the thyroid hormone transporter Mct8 in osteoblast and osteoclast progenitors both increases trabecular bone in male mice.
  Lademann F, Tsourdi E, Rijntjes E, Köhrle J, Hofbauer LC, Heuer H, Rauner M.
  Thyroid. 2020 Feb;30(2):329-342.
  
• Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.
  Rakov H, De Angelis M, Renko K, Hönes GS, Zwanziger D, Moeller LC, Schramm KW, Führer D.
  Thyroid. 2019 Dec;29(12):1723-1733
  
• Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 contribute to Inter-Individual Variance of Executive Functions and Personality Traits.
  Uter JC, M Krämer U, Schöls L, Rodriguez-Fornells A, Göbel A, Heldmann M, Lichtner P, Brabant G, F Münte T.
  Exp Clin Endocrinol Diabetes. 2019 Dec 9. doi: 10.1055/a-1065-1786. Erratum in: Exp Clin Endocrinol Diabetes. 2020 Jan 24
  
• Molecular Mechanisms of Thyroid Hormone Transport by l-Type Amino Acid Transporter
  Krause G, Hinz KM.
  Exp Clin Endocrinol Diabetes. 2019 Nov 18. [Epub ahead of print]
  
• Tissue-Specific Function of Thyroid Hormone Transporters: New Insights from Mouse Models.
  Salveridou E, Mayerl S, Sundaram SM, Markova B, Heuer H.
  Exp Clin Endocrinol Diabetes 2019 Nov 13. Epub ahead of print
  
• 3-Iodothyronamine Induces Diverse Signaling Effects at Different Aminergic and Non-Aminergic G-Protein Coupled Receptors.
  Biebermann H, Kleinau G.
  Exp Clin Endocrinol Diabetes. 2019 Nov 7. [Epub ahead of print]
  
• Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice
  Kohler H, Latteyer S, Hönes GS, Theurer S, Liao XH, Christoph S, Zwanziger D, Schulte JH, Kero J, Undeutsch H, Refetoff S, Schmid KW, Führer D, Moeller LC
  Thyroid. 2019 Oct;29(10):1438-1446.
  
• Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison.
  Walter KM, Dach K, Hayakawa K, Giersiefer S, Heuer H, Lein PJ, et al.
  PLoS ONE (2019); 14(9): e0221230.
  
• Thyroid Related Quality of Life in Elderly with Subclinical Hypothyroidism and Improvement on Levothyroxine is Distinct from that in Young Patients (TSAGE).
  Recker S, Voigtländer R, Viehmann A, Dunschen K, Kerp H, Frank-Raue K, Leidig-Bruckner G, Graf D, Lederbogen S, Dietrich JW, Görges R, Brabant G, Völker U, Watt T, Zwanziger D, Moeller LC, Führer D
  Horm Metab Res. 2019 Sep;51(9):568-574. Epub ahead of print
  
• Aging Alters Phenotypic Traits of Thyroid Dysfunction in Male Mice With Divergent Effects on Complex Systems but Preserved Thyroid Hormone Action in Target Organs.
  Engels K, Rakov H, Hönes GS, Brix K, Köhrle J, Zwanziger D, Moeller LC, Führer D.
  J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1162-1169
  
• A combined LC-MS/MS and LC-MS3 multi-method for the quantification of iodothyronines in human blood serum.
  Richards KH, Monk R, Renko K, Rathmann D, Rijntjes E, Köhrle J.
  Analytical and Bioanalytical Chemistry 411(21):5605-5616. Epub ahead of print
  
• Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption
  Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JD, Backes H, Mittag J.
  Cell Reports, Volume 27, Issue 11, P3385-3400.e3, June 11, 2019
  
• Tetrac as an anti-angiogenic agent in cancer.
  Schmohl KA, Nelson PJ, Spitzweg C.
  Endocr Relat Cancer. 2019 Jun 1;26(6):R287-R304. doi: 10.1530/ERC-19-0058.
  
• Machine Learning Based Classification of Resting-State fMRI Features Exemplified by Metabolic State (Hunger/Satiety).
  Al-Zubaidi A, Mertins A, Heldmann M, Jauch-Chara K, Münte TF.
  Front Hum Neurosci. 2019;13:164
  
• The colorful diversity of thyroid hormone metabolites.
  Köhrle J.
  Eur Thyroid J 2019;8:115–129
  
• Thyroid Hormone Metabolism
  Köhrle J.
  Ilpo Huhtaniemi and Luciano Martini, (Eds.), Encyclopedia of Endocrine Diseases, Second Edition, 2019, vol. 4, pp. 420–428.
  
• Partial withdrawal of levothyroxine treated disease leads to brain activations and effects on performance in a working memory task: A pilot study.
  Göbel A, Heldmann M, Göttlich M, Goerges R, Nieberding R, Sartorius A, Brabant G, Münte TF.
  J Neuroendocrinol Apr;31(4):e12707
  
• 3-Iodothyronamine-A Thyroid Hormone Metabolite With Distinct Target Profiles and Mode of Action.
  Köhrle J, Biebermann H.
  Endocr Rev. 2019 Apr 1;40(2):602-630. doi: 10.1210/er.2018-00182.
  
• Association Between 3-Iodothyronamine (T1am) Concentrations and Left Ventricular Function in Chronic Heart Failure.
  la Cour JL, Christensen HM, Köhrle J, Lehmphul I, Kistorp C, Nygaard B, Faber J.
  J Clin Endocrinol Metab. 2019 Apr 1;104(4):1232-1238. doi: 10.1210/jc.2018-01466.
  
• Circulating Adipokine VASPIN Is Associated with Serum Lipid Profiles in Humans.
  Breitfeld J, Wiele N, Gutsmann B, Stumvoll M, Blüher M, Scholz M, Kovacs P, Tönjes A.
  Lipids. 2019 Apr;54(4):203-210. doi: 10.1002/lipd.12139. Epub 2019 Mar 18.
  
• The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats.
  Šošić-Jurjević B, Lütjohann D, Renko K, Filipovic B, Ajdzanovic V, Trifunovic S, Nestorovic N, Zivanovic J, Manojlović-Stojanoski M, Köhrle J, Milosevic V.
  J Steroid Biochem Mol Biol. 2019 Mar 15;190:1-10. doi: 10.1016/j.jsbmb.2019.03.009. [Epub ahead of print]
  
• The Role of Dickkopf-1 in Thyroid Hormone-Induced Changes of Bone Remodeling in Male Mice.
  Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC, Rauner M.
  Endocrinology. 2019 Mar 1;160(3):664-674. doi: 10.1210/en.2018-00998.
  
• Thyroxine promotes lung cancer growth in an orthotopic mouse model.
  Latteyer S, Christoph S, Theurer S, Hönes GS, Schmid KW, Fuehrer D, Moeller LC.
  Endocr Relat Cancer. 2019 Mar 1. pii: ERC-18-0353.R1. doi: 10.1530/ERC-18-0353. [Epub ahead of print] PMID: 30893642
  
• Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organs
  Engels, K, Rakov H, Hönes GS, Brix K, Köhrle J, Zwanziger D, Moeller LC, Führer D.
  J Gerontol A Biol Sci Med Sci. 2019 Feb 16. pii: glz040. doi: 10.1093/gerona/glz040. [Epub ahead of print]
  
• Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression
  Urnauer S, Schmohl KA, Tutter M, Schug C, Schwenk N, Morys S, Ziegler S, Bartenstein P, Clevert DA, Wagner E, Spitzweg C.
  Gene Ther. 2019 Apr;26(3-4):93-108. doi: 10.1038/s41434-019-0059-6. Epub 2019 Jan 25.
  
• Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis.
  Krause C, Grohs M, El Gammal A, Wolter S, Lehnert H, Mann O, Mittag J, Kirchner H.
  Endocr Connect. 2018 Nov 1. pii: EC-18-0499. doi: 10.1530/EC-18-0499. [Epub ahead of print]
  
• Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.
  Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE, Geelhoed B, Guo X, Kleber ME, Lin HJ, Lin H, MacFarlane P, Selvin E, Shaffer C, Smith AV, Verweij N, Weiss S, Cappola AR, Dörr M, Gudnason V, Heckbert S, Mooijaart S, März W, Psaty BM, Ridker PM, Roden D, Stott DJ, Völzke H, Benjamin EJ, Delgado G, Ellinor P, Homuth G, Köttgen A, Jukema JW, Lubitz SA, Mora S, Rienstra M, Rotter JI, Shoemaker MB, Sotoodehnia N, Taylor KD, van der Harst P, Albert CM, Chasman DI.
  JAMA Cardiol. 2019 Jan 23. doi: 10.1001/jamacardio.2018.4635. [Epub ahead of print]
  
• Aortic Effects of Thyroid Hormone in Male Mice.
  Gachkar S, Nock S, Geissler C, Ölkrug R, Johann K, Resch J, Rahman A, Arner A, Kirchner H, Mittag J.
  J Mol Endocrinol. 2019 Jan 1. pii: JME-18-0217.R1. doi: 10.1530/JME-18-0217. [Epub ahead of print]
  
• TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer.
  Schug C, Urnauer S, Jaeckel C, Schmohl KA, Tutter M, Steiger K, Schwenk N, Schwaiger M, Wagner E, Nelson PJ, Spitzweg C.
  Endocr Relat Cancer. 2019 Jan 1;26(1):89-101. doi: 10.1530/ERC-18-0173.
  
• Experimentally induced subclinical hypothyroidism causes decreased functional connectivity of the cuneus: A resting state fMRI study.
  Göbel A, Göttlich M, Heldmann M, Georges R, Nieberding R, Rogge B, Sartorius A, Brabant G, Münte TF.
  Psychoneuroendocrinology 102:158-163. Epub ahead of print
  
• The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women.
  Sathyapalan T, Köhrle J, Rijntjes E, Rigby AS, Dargham SR, Kilpatrick ES, Atkin SL.
  Front Endocrinol (Lausanne). 2018 Nov 22;9:698. doi: 10.3389/fendo.2018.00698. eCollection 2018.
  
• Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes.
  Türker E, Garreis F, Khajavi N, Reinach PS, Joshi P, Brockmann T, Lucius A, Ljubojevic N, Turan E, Cooper D, Schick F, Reinholz R, Pleyer U, Köhrle J, Mergler S.
  Front Endocrinol (Lausanne). 2018 Nov 22;9:670. doi: 10.3389/fendo.2018.00670. eCollection 2018.
  
• TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells.
  Walcher L, Budde C, Böhm A, Reinach P, Dhandapani P, Ljubojevic N, Schweiger M, von der Waydbrink H, Reimers I, Köhrle J, Mergler S.
  Front Pharmacol. 2018 Nov 13;9:1234. doi: 10.3389/fphar.2018.01234. eCollection 2018.
  
• Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
  Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, Schultheiss UT, Traglia M, Ahluwalia TS, Akiyama M, Appel EVR, Arking DE, Arnold A, Astrup A, Beekman M, Beilby JP, Bekaert S, Boerwinkle E, Brown SJ, De Buyzere M, Campbell PJ, Ceresini G, Cerqueira C, Cucca F, Deary IJ, Deelen J, Eckardt KU, Ekici AB, Eriksson JG, Ferrrucci L, Fiers T, Fiorillo E, Ford I, Fox CS, Fuchsberger C, Galesloot TE, Gieger C, Gögele M, De Grandi A, Grarup N, Greiser KH, Haljas K, Hansen T, Harris SE, van Heemst D, den Heijer M, Hicks AA, den Hollander W, Homuth G, Hui J, Ikram MA, Ittermann T, Jensen RA, Jing J, Jukema JW, Kajantie E, Kamatani Y, Kasbohm E, Kaufman JM, Kiemeney LA, Kloppenburg M, Kronenberg F, Kubo M, Lahti J, Lapauw B, Li S, Liewald DCM; Lifelines Cohort Study, Lim EM, Linneberg A, Marina M, Mascalzoni D, Matsuda K, Medenwald D, Meisinger C, Meulenbelt I, De Meyer T, Meyer Zu Schwabedissen HE, Mikolajczyk R, Moed M, Netea-Maier RT, Nolte IM, Okada Y, Pala M, Pattaro C, Pedersen O, Petersmann A, Porcu E, Postmus I, Pramstaller PP, Psaty BM, Ramos YFM, Rawal R, Redmond P, Richards JB, Rietzschel ER, Rivadeneira F, Roef G, Rotter JI, Sala CF, Schlessinger D, Selvin E, Slagboom PE, Soranzo N, Sørensen TIA, Spector TD, Starr JM, Stott DJ, Taes Y, Taliun D, Tanaka T, Thuesen B, Tiller D, Toniolo D, Uitterlinden AG, Visser WE, Walsh JP, Wilson SG, Wolffenbuttel BHR, Yang Q, Zheng HF, Cappola A, Peeters RP, Naitza S, Völzke H, Sanna S, Köttgen A, Visser TJ, Medici M.
  Nat Commun. 2018 Oct 26;9(1):4455. doi: 10.1038/s41467-018-06356-1.
  
• Circulating Pro-Neurotensin in gestational diabetes mellitus.
  Tönjes A, Kralisch S, Hoffmann A, Schleinitz D, Kratzsch J, Blüher M, Stumvoll M, Kovacs P, Fasshauer M, Ebert T.
  Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):23-29. doi: 10.1016/j.numecd.2018.09.011. Epub 2018 Oct 20.
  
• Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.
  Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Karra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK.
  J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855
  
• Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO): a randomised, observer-masked, multicentre trial.
  Kahaly GJ, Riedl M, König J, Pitz S, Ponto K, Diana T, Kampmann E, Kolbe E, Eckstein A, Moeller LC, Führer D, Salvi M, Curro N, Campi I, Covelli D, Leo M, Marinò M, Menconi F, Marcocci C, Bartalena L, Perros P, Wiersinga WM; European Group on Graves' Orbitopathy (EUGOGO).
  Lancet Diabetes Endocrinol. 2018 Apr;6(4):287-298. Epub ahead of print
  
• A Novel Approach for Image-Guided 131I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery.
  Schug C, Gupta A, Urnauer S, Steiger K, Cheung PF, Neander C, Savvatakis K, Schmohl KA, Trajkovic-Arsic M, Schwenk N, Schwaiger M, Nelson PJ, Siveke JT, Spitzweg C.
  Mol Cancer Res. 2019 Jan;17(1):310-320. doi: 10.1158/1541-7786.MCR-18-0185. Epub 2018 Sep 17.
  
• 3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines.
  Bräunig J, Mergler S, Jyrch S, Hoefig CS, Rosowski M, Mittag J, Biebermann H, Khajavi N.
  Front Endocrinol (Lausanne). 2018 Sep 11;9:523. doi: 10.3389/fendo.2018.00523. eCollection 2018.
  
• Graves’ orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse model
  Schlüter A, Flögel U, Diaz-Cano S, Görtz G-E, Stähr K, Oeverhaus M, Plöhn S, Mattheis S, Moeller LC, Lang S, Bechrakis NE, Banga JP, Eckstein A, Berchner-Pfannschmidt U.
  Sci Rep. 2018; 8: 13096
  
• The affinity of antipsychotic drugs to dopamine and serotonin 5-HT2 receptors determines their effects on prefrontal-striatal functional connectivity.
  Tollens F, Gass N, Becker R, Schwarz AJ, Risterucci C, Künnecke B, Lebhardt P, Reinwald J, Sack M, Weber-Fahr W, Meyer-Lindenberg A, Sartorius A.
  Eur Neuropsychopharmacol. 2018 Sep;28(9):1035-1046. doi: 10.1016/j.euroneuro.2018.05.016. Epub 2018 Jul 10.
  
• [Impact of thyroid diseases on bone].
  Tsourdi E, Lademann F, Siggelkow H.
  Internist (Berl). 2018 Jul;59(7):661-667. doi: 10.1007/s00108-018-0436-z.
  
• Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets.
  Köhrle J.
  Methods Mol Biol. 2018;1801:85-104. doi: 10.1007/978-1-4939-7902-8_9.
  
• Empowering thyroid hormone research in human subjects using OMICs technologies.
  Pietzner M, Kacprowski T, Friedrich N.
  J Endocrinol. 2018 Jul;238(1):R13-R29. doi: 10.1530/JOE-18-0117. Epub 2018 May 3.
  
• External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery.
  Schug C, Sievert W, Urnauer S, Müller AM, Schmohl KA, Wechselberger A, Schwenk N, Lauber K, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C.
  Hum Gene Ther. 2018 Nov;29(11):1287-1300. doi: 10.1089/hum.2018.025. Epub 2018 May 3.
  
• Comprehensive Metabolic Profiling Reveals a Lipid-Rich Fingerprint of Free Thyroxine Far Beyond Classic Parameters.
  Lange T, Budde K, Homuth G, Kastenmüller G, Artati A, Krumsiek J, Völzke H, Adamski J, Petersmann A, Völker U, Nauck M, Friedrich N, Pietzner M.
  J Clin Endocrinol Metab. 2018 May 1;103(5):2050-2060. doi: 10.1210/jc.2018-00183.
  
• Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)
  Sharlin DS, Ng L, Verrey F, Visser TJ, Liu Y, Olszewski RT, Hoa M, Heuer H, Forrest D.
  Scientific Reports, volume 8, Article number: 4403 (2018) doi:10.1038/s41598-018-22553-w
  
• Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration
  Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H, von Maltzahn J.
  Stem Cell Reports (2018), https://doi.org/10.1016/j.stemcr.2018.03.021
  
• Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.
  Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.
  J Neuroendocrinol. 2018 Mar;30(3):e12573. doi: 10.1111/jne.12573.
  
• Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression.
  Clemm von Hohenberg C, Weber-Fahr W, Lebhardt P, Ravi N, Braun U, Gass N, Becker R, Sack M, Cosa Linan A, Gerchen MF, Reinwald JR, Oettl LL, Meyer-Lindenberg A, Vollmayr B, Kelsch W, Sartorius A.
  Transl Psychiatry. 2018 Mar 27;8(1):68. doi: 10.1038/s41398-018-0121-y.
  
• Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression.
  Qatato M, Szumska J, Skripnik V, Rijntjes E, Köhrle J, Brix K.
  Front Pharmacol. 2018 Mar 20;9:221. doi: 10.3389/fphar.2018.00221. eCollection 2018.
  
• Effects of sildenafil treatment on thermogenesis and glucose homeostasis in diet-induced obese mice.
  Johann K, Reis MC, Harder L, Herrmann B, Gachkar S, Mittag J, Oelkrug R.
  Nutr Diabetes. 2018 Mar 13;8(1):9. doi: 10.1038/s41387-018-0026-0.
  
• The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor.
  Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H.
  Front Pharmacol. 2018 Mar 12;9:222. doi: 10.3389/fphar.2018.00222. eCollection 2018.
  
• Relationship Between 12 Adipocytokines and Distinct Components of the Metabolic Syndrome.
  Ebert T, Gebhardt C, Scholz M, Wohland T, Schleinitz D, Fasshauer M, Blüher M, Stumvoll M, Kovacs P, Tönjes A.
  J Clin Endocrinol Metab. 2018 Mar 1;103(3):1015-1023. doi: 10.1210/jc.2017-02085.
  
• Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.
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• Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer.
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  Endocrine. 2016 Dec;54(3):733-741. doi: 10.1007/s12020-016-1080-9. Epub 2016 Oct 1.
  
• Thyronamines and derivatives: Physiological relevance, pharmacological actions and future research directions.
  Hoefig CS, Zucchi R, Koehrle J.
  Thyroid. 2016 Dec;26(12):1656-1673. Epub 2016 Nov 9. PMID: 27650974.
  
• Genome-wide associations for birth weight and correlations with adult disease.
  Horikoshi M, Beaumont RN, Day FR, Warrington NM, et al.
  Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806. Epub 2016 Sep 28.
  
• Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice.
  Rakov H, Engels K, Hönes GS, Strucksberg KH, Moeller LC, Köhrle J, Zwanziger D, Führer D.
  Biol Sex Differ. 2016 Aug 24;7(1):36. doi: 10.1186/s13293-016-0089-3. PMID:27559466.
  
• Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery.
  Müller AM, Schmohl KA, Knoop K, Schug C, Urnauer S, Hagenhoff A, Clevert DA, Ingrisch M, Niess H, Carlsen J, Zach C, Wagner E, Bartenstein P, Nelson PJ, Spitzweg C.
  Oncotarget. 2016 Aug 23;7(34):54795-54810. doi: 10.18632/oncotarget.10758.
  
• Effect of Mild Thyrotoxicosis on Performance and Brain Activations in a Working Memory Task
  Göbel A, Heldmann M, Göttlich M, Dirk A-L, Brabant G and Münte TF.
  PLoS One. 2016; 11(8): e0161552. Epub ahead of print
  
• Selenium status in neonates with connatal infection.
  Wiehe L, Cremer M, Wisniewska M, Becker NP, Rijntjes E, Martitz J, Hybsier S, Renko K, Bührer C, Schomburg L.
  Br J Nutr. 2016 Aug;116(3):504-13. doi: 10.1017/S0007114516002208. Epub 2016 Jun 8.
  
• Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10.
  Johannes J, Braun D, Kinne A, Rathmann D, Köhrle J, Schweizer U.
  Mol Endocrinol. 2016 Jul;30(7):796-808. doi: 10.1210/me.2016-1037. PMID:27244477
  
• Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.
  Walford GA, Gustafsson S, Rybin D, Stančáková A, et al.
  Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. Epub 2016 Jul 14.
  
• The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.
  Zwanziger D, Schmidt M, Fischer J, Kleinau G, Braun D, Schweizer U, Moeller LC, Biebermann H, Fuehrer D.
  Mol Cell Endocrinol. 2016 May 21. pii: S0303-7207(16)30175-7. doi: 10.1016/j.mce.2016.05.017. [Epub ahead of print]. PMID: 27222294
  
• Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
  Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, et al.
  Aging Cell. 2016 Oct;15(5):811-24. doi: 10.1111/acel.12490. Epub 2016 Jun 21.
  
• Harnessing mesenchymal stem cell homing as an anticancer therapy.
  Hagenhoff A, Bruns CJ, Zhao Y, von Lüttichau I, Niess H, Spitzweg C, Nelson PJ.
  Expert Opin Biol Ther. 2016 Sep;16(9):1079-92. doi: 10.1080/14712598.2016.1196179. Epub 2016 Jun 13. Review.
  
• New drugs for medullary thyroid cancer: new promises?
  Spitzweg C, Morris JC, Bible KC.
  Endocr Relat Cancer. 2016 Jun;23(6):R287-97. doi: 10.1530/ERC-16-0104. Epub 2016 May 16. Review.
  
• Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice.
  Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J.
  Endocrinology. 2016 May 4:en20161095. [Epub ahead of print]
  
• Sequence-defined cMET/HGFR-targeted Polymers as Gene Delivery Vehicles for the Theranostic Sodium Iodide Symporter (NIS) Gene.
  Urnauer S, Morys S, Krhac Levacic A, Müller AM, Schug C, Schmohl KA, Schwenk N, Zach C, Carlsen J, Bartenstein P, Wagner E, Spitzweg C.
  Mol Ther. 2016 Aug;24(8):1395-404. doi: 10.1038/mt.2016.95. Epub 2016 May 9.
  
• Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men.
  Beukhof CM, Medici M, van den Beld AW, Hollenbach B, Hoeg A, Visser WE, de Herder WW, Visser TJ, Schomburg L, Peeters RP.
  PLoS One. 2016 Apr 7;11(4):e0152748. doi: 10.1371/journal.pone.0152748. eCollection 2016.PMID:27055238.
  
• Efficient activation of pathogenic Phe501 mutation in monocarboxylate transporter 8 by chemical and pharmacological chaperones
  Braun D, Schweizer U.
  Endocrinology 2015 Dec 14;156(12):4720-30. Epub 2015 Sep 14.
  
• Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones.
  Mondal S, Raja K, Schweizer U, Mugesh G.
  Angew Chem Int Ed Engl. 2016 Jun 27;55(27):7606-30. doi: 10.1002/anie.201601116. Epub 2016 May 25.
  
• Biosynthesis of 3-Iodothyronamine From T4 in Murine Intestinal Tissue.
  Hoefig CS, Wuensch T, Rijntjes E, Lehmphul I, Daniel H, Schweizer U, Mittag J, Köhrle J.
  Endocrinology. 2015 Nov;156(11):4356-64. doi: 10.1210/en.2014-1499. Epub 2015 Sep 8. PMID:26348473 [PubMed - indexed for MEDLINE]
  
• Association of antiepileptic drug usage, trace elements and thyroid hormone status.
  Zevenbergen C, Korevaar TI, Schuette A, Peeters RP, Medici M, Visser TJ, Schomburg L, Visser WE.
  Eur J Endocrinol. 2016 Apr;174(4):425-32. doi: 10.1530/EJE-15-1081. Epub 2015 Dec 23. PMID:26701870.
  
• Silychristin, a flavonolignan derived from the milk thistle is a potent inhibitor of the thyroid hormone transporter MCT8
  Johannes J, Jayarama-Naidu R, Meyer F, Wirth EK, Schweizer U, Schomburg L, Köhrle J, Renko K.
  Endocrinology. 2016 Apr;157(4):1694-701. doi: 10.1210/en.2015-1933. Epub 2016 Feb 24. PMID: 26910310.
  
• High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population.
  Ittermann T, Lorbeer R, Dörr M, Schneider T, Quadrat A, Heßelbarth L, Wenzel M, Lehmphul I, Köhrle J, Mensel B, Völzke H.
  Eur Radiol. 2016 Mar 14. [Epub ahead of print]. PMID: 26973144 [PubMed - as supplied by publisher]
  
• 3,5-T2 alters murine genes relevant for xenobiotic, steroid and thyroid hormone metabolism.
  Lietzow J, Golchert J, Homuth G, Völker U, Jonas W, Köhrle J.
  J Mol Endocrinol. 2016 Feb 22. pii: JME-15-0159 [Epub ahead of print]. PMID:26903510 [PubMed - as supplied by publisher]
  
• A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2A.
  Latteyer S, Klein-Hitpass L, Khandanpour C, Zwanziger D, Poeppel TD, Schmid KW, Führer D, Moeller LC.
  J Clin Endocrinol Metab. 2016 Mar;101(3):1016-22. doi: 10.1210/jc.2015-2948. Epub 2016 Jan 14. PMID:26765577 [PubMed - in process]
  
• Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves' Ophthalmopathy.
  Dehina N, Hofmann PJ, Behrends T, Eckstein A, Schomburg L.
  Eur Thyroid J. 2016 Mar;5(1):57-64. doi: 10.1159/000442440. Epub 2016 Jan 16. PMID:27099840.
  
• New insights into the structure and mechanism of iodothyronine deiodinases.
  Schweizer U, Steegborn C.
  J Mol Endocrinol. 2015 Dec;55(3):R37-52. doi: 10.1530/JME-15-0156. Epub 2015 Sep 21. PMID: 26390881 [PubMed - in process]
  
• Thyroid hormones-From Crystal Packing to Activity to Reactivity.
  Schweizer U, Steegborn C.
  Angew Chem Int Ed Engl. 2015 Oct 26;54(44):12856-8. doi: 10.1002/anie.201506919. Epub 2015 Sep 11. PMID: 26358899 [PubMed - in process]
  
• Thyroid-Stimulating Hormone and Mild Cognitive Impairment: Results of the Heinz Nixdorf Recall Study.
  Winkler A, Weimar C, Jöckel KH, Erbel R, Dragano N, Broecker-Preuss M, Moebus S, Führer-Sakel D, Dlugaj M.
  J Alzheimers Dis. 2016;49(3):797-807. doi: 10.3233/JAD-150561.
  
• Transport of Iodothyronines by human L-Type Amino Acid Transporters
  Zevenbergen C, Meima ME, Peeters RP, Kinne A, Krause G, Visser WE, Visser TJ.
  Endocrinology 2015 Nov;156(11):4345-55.en20151140. [Epub ahead of print]
  
• Gene-specific regulation of hepatic selenoprotein expression by interleukin-6.
  Martitz J, Becker NP, Renko K, Stoedter M, Hybsier S, Schomburg L.
  Metallomics. 2015 Nov;7(11):1515-21. doi: 10.1039/c5mt00211g. Epub 2015 Sep 23.PMID:26399395.
  
• Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.
  Burkhardt R, Kirsten H, Beutner F, Holdt LM, Gross A, Teren A, Tönjes A, Becker S, Krohn K, Kovacs P, Stumvoll M, Teupser D, Thiery J, Ceglarek U, Scholz M.
  PLoS Genet. 2015 Sep 24;11(9):e1005510. doi: 10.1371/journal.pgen.1005510. eCollection 2015 Sep.
  
• Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3.
  Schmohl KA, Müller AM, Wechselberger A, Rühland S, Salb N, Schwenk N, Heuer H, Carlsen J, Göke B, Nelson PJ, Spitzweg C.
  Endocr Relat Cancer. 2015 Dec;22(6):941-52. doi: 10.1530/ERC-15-0245. Epub 2015 Aug 25.
  
• Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations.
  Ebert T, Kralisch S, Wurst U, Scholz M, Stumvoll M, Kovacs P, Fasshauer M, Tönjes A.
  Int J Obes (Lond). 2016 Feb;40(2):260-5. doi: 10.1038/ijo.2015.157. Epub 2015 Aug 19.
  
• Thyrotropin serum levels are differentially associated with biochemical markers of bone turnover and stiffness in women and men: results from the SHIP cohorts.
  Tsourdi E, Wallaschofski H, Rauner M, Nauck M, Pietzner M, Rettig R, Ittermann T, Völzke H, Völker U, Hofbauer LC, Hannemann A.
  Osteoporos Int. 2016 Feb;27(2):719-27. doi: 10.1007/s00198-015-3276-x. Epub 2015 Aug 12.
  
• Eating Behaviour in the General Population: An Analysis of the Factor Structure of the German Version of the Three-Factor-Eating-Questionnaire (TFEQ) and Its Association with the Body Mass Index.
  Löffler A, Luck T, Then FS, Sikorski C, Kovacs P, Böttcher Y, Breitfeld J, Tönjes A, Horstmann A, Löffler M, Engel C, Thiery J, Villringer A, Stumvoll M, Riedel-Heller SG.
  PLoS One. 2015 Jul 31;10(7):e0133977. doi: 10.1371/journal.pone.0133977. eCollection 2015.
  
• Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1.
  Endocrinology. 2015 Oct;156(10):3517-27. doi: 10.1210/en.2015-1073. Epub 2015 Jul 28.
  Tsourdi E, Rijntjes E, Köhrle J, Hofbauer LC, Rauner M.
  
• The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness.
  Zwanziger D, Badziong J, Ting S, Moeller LC, Schmid KW, Siebolts U, Wickenhauser C, Dralle H, Fuehrer D.
  Endocr Relat Cancer. 2015 Oct;22(5):819-30. doi: 10.1530/ERC-14-0502. Epub 2015 Jul 28.
  
• Higher Thyroid-Stimulating Hormone, Triiodothyronine and Thyroxine Values Are Associated with Better Outcome in Acute Liver Failure.
  Anastasiou O, Sydor S, Sowa JP, Manka P, Katsounas A, Syn WK, Führer D, Gieseler RK, Bechmann LP, Gerken G, Moeller LC, Canbay A.
  Plos one, 06 Jul 2015, 10(7):e0132189
  
• Distinct urinary metabolic profiles associated with serum TSH and FT4 concentrations
  Pietzner M, Budde K, Homuth G, Völker U, Völzke H, Nauck M, Wallaschofski H, Friedrich N.
  Metabolomics, October 2015, Volume 11, Issue 5, pp 1316–1326.
  
• Interaction of thyroid hormone with brown adipose tissue. Lessons learned from PET-CT.
  Steinhoff KG, Hankir M , Krause K, Tönjes A, Fenske WK, Sabri O, Hesse S.
  Nuklearmedizin. 2015 Jun 23;54(3):82-7; PMID: 26105715 [PubMed - in process]
  
• Understanding the healthy thyroid state in 2015
  Führer D, Brix K, Biebermann H.
  Eur Thyroid J 2015;4(suppl 1):1-8 (DOI:10.1159/000431318)
  
• Evolutionary conservation of 3-iodothyronamine as agonist at the trace amine-associated receptor 1
  Cöster M, Biebermann H, Schöneberg T, Stäubert C.
  Eur Thyroid J 2015;4(suppl 1):9-20 (DOI:10.1159/000430839)
  
• Trace amine-associated receptor 1 localization at the apical plasma membrane domain of Fisher rat thyroid epithelial cells is confined to cilia
  Szumska J, Qatato M, Rehders M, Führer D, Biebermann H, Grandy DK, Köhrle J, Brix K.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):30-41. doi: 10.1159/000434717. Epub 2015 Jun 10. PMID: 26601071 [PubMed]
  
• Quantitative analysis of thyroid hormone metabolites in cell culture samples using LC MS/MS
  Rathmann D, Rijntjes E, Lietzow J, Köhrle J.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):51-8. doi: 10.1159/000430840. Epub 2015 May 28. PMID: 26601073 [PubMed]
  
• The effects of thyroid hormones on gene expression of acyl-coenzyme A thioesterases in adipose tissue and liver of mice
  Krause K, Weiner J, Hönes S, Klöting N, Rijntjes E, Gebhardt C, Heiker JT, Köhrle J, Führer D, Steinhoff K, Hesse S, Moeller LC, Tönjes, A.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):59-66. doi: 10.1159/000437304. Epub 2015 Jul 2. PMID: 26601074 [PubMed]
  
• Establishment of an effective radioiodide thyroid ablation protocol in mice
  Schmohl KA, Müller AM, Schwenk N, Knoop K, Rijntjes E, Köhrle J, Heuer H, Bartenstein P, Göke B, Nelson PJ, Spitzweg C.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):74-80. doi: 10.1159/000381019. Epub 2015 May 23. PMID: 26601076 [PubMed]
  
• Differences in mouse hepatic thyroid hormone transporter expression with age and hyperthyroidism
  Engels K, Rakov H, Zwanziger D, Moeller LC, Homuth G, Koehrle J, Brix K, Fuhrer D.
  Eur Thyroid J 2015;4(suppl 1):81-86 (DOI:10.1159/000381020)
  
• High T3, low T4 serum levels in Mct8-deficiency are not caused by increased hepatic conversion through type I-deiodinase
  Wirth EK, Rijntjes E, Meyer F, Köhrle J, Schweizer U.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):87-91. doi: 10.1159/000381021. Epub 2015 May 23. PMID: 26601078 [PubMed]
  
• Urine metabolomics by 1H-NMR spectroscopy indicates associations between serum 3,5-T2 concentrations and intermediary metabolism in euthyroid humans
  Pietzner M, Homuth G, Budde K, Lehmphul I, Völker U, Völzke H, Nauck M, Köhrle J, Friedrich N.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):92-100. doi: 10.1159/000381308. Epub 2015 May 28. PMID: 26601079 [PubMed]
  
• Serum Thyrotropin Concentrations are not Associated with the Ankle-Brachial Index – Results from Three Population-Based Studies
  Ittermann T, Lorbeer R, Tiller D, Lehmphul I, Kluttig A, SB Felix, Werdan K, Greiser KH, Köhrle J, Völzke H, Dörr M.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):101-7. doi: 10.1159/000381309. Epub 2015 May 27. PMID: 26601080 [PubMed]
  
• Two novel mutations in the Serpina7 gene are associated with complete deficiency of thyroxine-binding globulin
  Moeller LC, Appiagyei-Dankah Y, Köhler B, Biebermann H, Janßen OE, Führer D.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):108-12. doi: 10.1159/000381093. Epub 2015 May 30. PMID: 26601081 [PubMed]
  
• Effect of experimental thyrotoxicosis onto blood coagulation – A proteomics study
  Engelmann B, Bischof J, Dirk, AL, Friedrich N, Hammer E Thiele T, Führer D, Homuth G, Brabant G, Völker U.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):119-24. doi: 10.1159/000381769. Epub 2015 May 28. PMID: 26601083 [PubMed]
  
• Sex-dependent claudin-1 expression in liver of eu- and hypothyroid mice
  Zwanziger D, Rakov H, Engels K, Moeller LC, Fuhrer D.
  Eur Thyroid J 2015;4(suppl 1):67-73 (DOI:10.1159/000431316)
  
• Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study.
  Göbel A, Heldmann M, Göttlich M, Dirk AL, Brabant G, Münte TF.
  Eur Thyroid J. 2015 Sep;4(Suppl 1):113-8. Epub ahead of print
  
• A nonradioactive uptake assay for rapid analysis of thyroid hormone transporter function.
  Jayarama-Naidu R, Johannes J, Meyer F, Wirth EK, Schomburg L, Köhrle J, Renko K.
  Endocrinology. 2015 Jul;156(7):2739-45. doi: 10.1210/en.2015-1016. Epub 2015 Apr 24. PMID: 25910050 [PubMed - indexed for MEDLINE]
  
• An improved non-radioactive screening method identifies genistein and xanthohumol as potent inhibitors of iodothyronine deiodinases.
  Renko K, Schäche S, Hoefig CS, Welsink T, Schwiebert C, Braun D, Becker NP, Koehrle J, Schomburg L.
  Thyroid. 2015 Aug;25(8):962-8. doi: 10.1089/thy.2015.0058. Epub 2015 Jun 25. PMID: 25962824 [PubMed - in process]
  
• The multi-target ligand 3-iodothyronamine modulates beta-adrenergic receptor 2 signaling.
  Dinter J, Khajavi N, Mühlhaus J, Wienchol CL, Cöster M, Hermsdorf T, Stäubert C, Köhrle J, Schöneberg T, Kleinau G, Mergler S, Biebermann H.
  Eur Thyroid J 2015;4(suppl 1):21-29 (DOI:10.1159/000381801)
  
• Structural insights into thyroid hormone transport mechanisms of the L-amino acid transporter 2
  Hinz KM, Meyer K, Kinne A, Schülein R, Köhrle J, Krause G.
  MolEndocrinology, May 2015 [Epub ahead of print]. Received: February 04, 2015. Accepted: May 01, 2015. First Published Online: May 06, 2015.
  
• Involvement of the L-type amino acid transporter Lat2 in the transport of 3.3`diio-dothyronines across the plasma membrane
  Kinne A, Wittner M, Wirth EK, Hinz KM, Schülein R, Köhrle J, Krause G.
  Eur Thyroid J. 2015 Sep; 4(Suppl 1): 42–50. Published online 2015 May 28. doi: 10.1159/000381542. PMCID: PMC4640293
  
• Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth.
  Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H.
  J Clin Endocrinol Metab. 2015 May;100(5):2090-7. doi: 10.1210/jc.2014-4466. Epub 2015 Mar 17. PMID: 25781359 [PubMed - indexed for MEDLINE]
  
• 3-iodothyronamine differentially modulates alpha-2A adrenergic receptor-mediated signaling.
  Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Höfig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.
  J Mol Endocrinol. 2015 Apr 15. pii: JME-15-0003. [Epub ahead of print] PMID: 25878061
  
• Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls.
  Ebert T, Kralisch S, Wurst U, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Tönjes A, Fasshauer M.
  Eur J Endocrinol. 2015 Jul;173(1):1-7. doi: 10.1530/EJE-14-0815. Epub 2015 Apr 7.
  
• Quantification of in vitro mesenchymal stem cell invasion into tumor spheroids using selective plane illumination microscopy.
  Rühland S, Wechselberger A, Spitzweg C, Huss R, Nelson PJ, Harz H.
  J Biomed Opt. 2015 Apr;20(4):040501. doi: 10.1117/1.JBO.20.4.040501.
  
• Indications for potential parent-of-origin effects within the FTO gene.
  Liu X, Hinney A, Scholz M, Scherag A, Tönjes A, Stumvoll M, Stadler PF, Hebebrand J, Böttcher Y.
  PLoS One. 2015 Mar 20;10(3):e0119206. doi: 10.1371/journal.pone.0119206. eCollection 2015.
  
• Experimentally induced thyrotoxicosis leads to increased connectivity in temporal lobe structures: a resting state fMRI study.
  Göttlich M, Heldmann M, Göbel A, Dirk AL, Brabant G, Münte TF.
  Psychoneuroendocrinology. 2015 Jun;56:100-9. Epub ahead of print
  
• Mesenchymal stem cell-mediated, tumor stroma-targeted radioiodine therapy of metastatic colon cancer using the sodium iodide symporter as theranostic gene.
  Knoop K, Schwenk N, Schmohl K, Müller A, Zach C, Cyran C, Carlsen J, Böning G, Bartenstein P, Göke B, Wagner E, Nelson PJ, Spitzweg C.
  J Nucl Med. 2015 Apr;56(4):600-6. doi: 10.2967/jnumed.114.146662. Epub 2015 Mar 5.
  
• Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
  Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H.
  PLoS One. 2015 Feb 23;10(2):e0117774. doi: 10.1371/journal.pone.0117774. eCollection 2015.
  
• Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds.
  Stoedter M, Renko K, Ibáñez E, Plano D, Becker NP, Martitz J, Palop JA, Calvo A, Sanmartín C, Schomburg L.
  Metallomics. 2015 Feb 11;7(2):347-54. doi: 10.1039/c4mt00273c.PMID: 25579002[PubMed - in process]
  
• Performance monitoring and behavioural adaptation during task switching: an fMRI study.
  von der Gablentz J, Tempelmann C, Münte TF, Heldmann M.
  Neuroscience; 285:227-35
  
• Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.
  Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.
  J Mol Endocrinol. 2015 Feb;54(1):39-50. doi: 10.1530/JME-14-0272. PMID: 25527620
  
• A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer.
  Ferrara AM, Pappa T, Fu J, Brown CD, Peterson A, Moeller LC, Wyne K, White KP, Pluzhnikov A, Trubetskoy V, Nobrega M, Weiss RE, Dumitrescu AM, Refetoff S.
  J Clin Endocrinol Metab. 2015 Jan;100(1):E173-81.
  
• Absence of TRH-receptor 1 in male mice affects gastric ghrelin production
  Mayerl S, Liebsch C, Visser TJ, Heuer H.
  Endocrinology. doi: 10.1210/en.2014-1395. Received: May 15, 2014. Accepted: December 04, 2014. Published Online: December 09, 2014
  
• Circulating angiopoietin-like protein 8 is independently associated with fasting plasma glucose and type 2 diabetes mellitus.
  Ebert T1, Kralisch S, Hoffmann A, Bachmann A, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Tönjes A, Fasshauer M.
  J Clin Endocrinol Metab. 2014 Dec;99(12):E2510-7. doi: 10.1210/jc.2013-4349.
  
• Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells
  Khajavi N, Reinach PS, Slavi N, Skrzypski M, Lucius A, Strauß O, Köhrle J, Mergler S.
  Cellular Signalling, Volume 27, Issue 2, February 2015, Pages 315–325. doi:10.1016/j.cellsig.2014.11.015. Received: 16 September 2014. Received in revised form: 31 October 2014. Accepted: 12 November 2014. Available online: 21 November 2014
  
• [SPP-related publication] In Vitro and Mouse Studies Supporting Therapeutic Utility of Triiodothyroacetic Acid in MCT8 Deficiency.
  Kersseboom S, Horn S, Visser WE, Chen J, Friesema EC, Vaurs-Barrière C, Peeters RP, Heuer H, Visser TJ.
  Mol Endocrinol. 2014 Nov 12:me20141135. [Epub ahead of print] doi: 10.1210/me.2014-1135
  
• Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile
  Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Chun-Xia Yi, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H.
  Int. J. Mol. Sci. 2014, 15, 20638-20655. doi:10.3390/ijms151120638. Received: 3 August 2014; in revised form: 25 October 2014. Accepted: 4 November 2014. Published: 10 November 2014
  
• Translating pharmacological findings from hypothyroid rodents to euthyroid humans: Is there a functional role of endogenous 3,5-T2?
  Pietzner M, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R, Völker U, Brabant G, Völzke H, Koehrle J, Homuth G, Wallaschofski H.
  doi:10.1089/thy.2014.0262 Thyroid. 2014 Oct 24. [Epub ahead of print]
  
• 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male dietinduced obese mice.
  Jonas W, Lietzow J, Wohlgemuth F, Hoefig CS, Wiedmer P, Schweizer U, Köhrle J, Schürmann A.
  Endocrinology. 2014 Oct 16:en20141604. [Epub ahead of print] PMID:25322465
  
• High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population.
  Ittermann T, Dörr M, Völzke H, Tost F, Lehmphul I, Köhrle J, Jürgens C.
  Thyroid. 2014 Oct;24(10):1473-8. doi: 10.1089/thy.2014.0190. PMID:25156414 [PubMed - in process]
  
• Constitutive activities in the thyrotropin receptor: regulation and significance
  Kleinau G, Biebermann H.
  Adv Pharmacol. 2014;70:81-119. doi:10.1016/B978-0-12-417197-8.00003-1. PMID:24931193 [PubMed - in process]
  
• Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets.
  Spitzweg C, Bible KC, Hofbauer LC, Morris JC.
  Lancet Diabetes Endocrinol. 2014 Oct;2(10):830-42. doi: 10.1016/S2213-8587(14)70051-8. Epub 2014 Jun 2. PMID:24898835 [PubMed - in process]
  
• Structure and Function of Thyroid Hormone Plasma Membrane Transporters
  Schweizer U, Johannes J, Bayer D, Braun D.
  Published online: September 10, 2014, Eur Thyroid J 2014;3:143-153. doi:10.1159/000367858
  
• Serum thyroid-stimulating hormone levels are not associated with exercise capacity and lung function parameters in two population-based studies.
  Ittermann T, Gläser S, Ewert R, Felix S, Völzke H, Dörr M.
  BMC Pulm Med. 2014 Sep 2;14:145. doi: 10.1186/1471-2466-14-145. PMID:25182209 [PubMed - in process]
  
• Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody-based chemiluminescence immunoassay.
  Lehmphul I, Brabant G, Wallaschofski H, Ruchala M, Strasburger CJ, Köhrle J, Wu Z.
  Thyroid. 2014 Sep;24(9):1350-60. doi: 10.1089/thy.2013.0688. Epub 2014 Aug 1. PMID:24967815
  
• Progression of coronary artery calcification seems to be inevitable, but predictable - results of the Heinz Nixdorf Recall (HNR) study.
  Erbel R, Lehmann N, Churzidse S, Rauwolf M, Mahabadi AA, Möhlenkamp S, Moebus S, Bauer M, Kälsch H, Budde T, Montag M, Schmermund A, Stang A, Führer-Sakel D, Weimar C, Roggenbuck U, Dragano N, Jöckel KH; Heinz Nixdorf Recall Study Investigators.
  Eur Heart J. 2014 Nov 7;35(42):2960-71. doi: 10.1093/eurheartj/ehu288. Epub 2014 Jul 25.
  
• Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.
  Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE.
  Int J Cancer. 2015 Mar 1;136(5):1149-61. doi: 10.1002/ijc.29071. Epub 2014 Jul 21.
  
• Transport of thyroid hormone in brain.
  Wirth EK, Schweizer U, Köhrle J.
  Front Endocrinol (Lausanne). 2014 Jun 24;5:98. doi: 10.3389/fendo.2014.00098. eCollection 2014. Review. PMID:25009532 [PubMed]
  
• Expression pattern of thyroid hormone transporters in the postnatal mouse brain
  Müller J, Heuer H.
  Front. Endocrinol., 18 June 2014 | doi: 10.3389/fendo.2014.00092
  
• [SPP-related publication] - Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
  Schweizer U, Schlicker C, Braun D, Köhrle J, Steegbornd C.
  Published online before print July 7, 2014, doi:10.1073/pnas.1323873111 PNAS July 7, 2014
  
• Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors.
  Illouz F, Braun D, Briet C, Schweizer U, Rodien P.
  Eur J Endocrinol. 2014 Sep;171(3):R91-9. doi: 10.1530/EJE-14-0198. Epub 2014 May 15. Review.
  
• Selenoprotein P is the essential selenium transporter for bones.
  Pietschmann N, Rijntjes E, Hoeg A, Stoedter M, Schweizer U, Seemann P, Schomburg L.
  Metallomics. 2014 May;6(5):1043-9. doi: 10.1039/c4mt00003j.PMID: 24626785 [PubMed - indexed for MEDLINE]
  
• Hypoxia reduces and redirects selenoprotein biosynthesis.
  Becker NP, Martitz J, Renko K, Stoedter M, Hybsier S, Cramer T, Schomburg L.
  Metallomics. 2014 May;6(5):1079-86. doi: 10.1039/c4mt00004h. PMID: 24700164 [PubMed - indexed for MEDLINE]
  
• Soy isoflavones interfere with thyroid hormone homeostasis in orchidectomized middle-aged rats.
  Šošić-Jurjević B, Filipović B, Wirth EK, Živanović J, Radulović N, Janković S, Milošević V, Köhrle J.
  Toxicol Appl Pharmacol. 2014 Jul 15;278(2):124-34. doi: 10.1016/j.taap.2014.04.018. Epub 2014 Apr 29.
  
• Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
  Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H.
  J Clin Invest. 2014 May 1;124(5):1987-99. Epub 2014 Apr 1. [PMID:24691440]
  
• [Thyroid hormone action beyond classical concepts. The priority programme "Thyroid Trans Act" (SPP 1629) of the German Research Foundation]
  Führer D, Brix K, Biebermann H.
  Dtsch Med Wochenschr. 2014 Mar;139(10):492-6. doi: 10.1055/s-0034-1369822. Epub 2014 Feb 25. Review. German.
  
• Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
  Medici M, Porcu E, Pistis G, Teumer A, Brown SJ, Jensen RA, Rawal R, Roef GL, Plantinga TS, Vermeulen SH, Lahti J, Simmonds MJ, Husemoen LL, Freathy RM, Shields BM, Pietzner D, Nagy R, Broer L, Chaker L, Korevaar TI, Plia MG, Sala C, Völker U, Richards JB, Sweep FC, Gieger C, Corre T, Kajantie E, Thuesen B, Taes YE, Visser WE, Hattersley AT, Kratzsch J, Hamilton A, Li W, Homuth G, Lobina M, Mariotti S, Soranzo N, Cocca M, Nauck M, Spielhagen C, Ross A, Arnold A, van de Bunt M, Liyanarachchi S, Heier M, Grabe HJ, Masciullo C, Galesloot TE, Lim EM, Reischl E, Leedman PJ, Lai S, Delitala A, Bremner AP, Philips DI, Beilby JP, Mulas A, Vocale M, Abecasis G, Forsen T, James A, Widen E, Hui J, Prokisch H, Rietzschel EE, Palotie A, Feddema P, Fletcher SJ, Schramm K, Rotter JI, Kluttig A, Radke D, Traglia M, Surdulescu GL, He H, Franklyn JA, Tiller D, Vaidya B, de Meyer T, Jørgensen T, Eriksson JG, O'Leary PC, Wichmann E, Hermus AR, Psaty BM, Ittermann T, Hofman A, Bosi E, Schlessinger D, Wallaschofski H, Pirastu N, Aulchenko YS, de la Chapelle A, Netea-Maier RT, Gough SC, Meyer Zu Schwabedissen H, Frayling TM, Kaufman JM, Linneberg A, Räikkönen K, Smit JW, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Walsh JP, Meisinger C, den Heijer M, Visser TJ, Spector TD, Wilson SG, Völzke H, Cappola A, Toniolo D, Sanna S, Naitza S, Peeters RP.
  PLoS Genet. 2014 Feb 27;10(2):e1004123. doi: 10.1371/journal.pgen.1004123. eCollection 2014 Feb.
  
• Authentic Bosutinib Inhibits T3-Transport by Monocarboxylate Transporter 8 (MCT8).
  Braun D, Schweizer U.
  Thyroid. 2014 Jan 30. Epub ahead of print. [PMID:24479416]
  
• Tissue-Specific Alterations in Thyroid Hormone Homeostasis in Combined Mct10 and Mct8 Deficiency.
  Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H.
  Endocrinology. 2014 Jan;155(1):315-25. doi: 10.1210/en.2013-1800. Epub 2013 Dec 20. [PMID: 24248460]
  
• EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene.
  Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C.
  Mol Ther Nucleic Acids. 2013 Nov 5;2:e131. doi: 10.1038/mtna.2013.58. PMID:24193032 [PubMed] PMCID:PMC3889187
  
• Sex-specific associations between thyrotropin and serum lipid profiles.
  Meisinger C, Ittermann T, Tiller D, Agger C, Nauck M, Schipf S, Wallaschofski H, Jørgensen T, Linneberg A, Thiery J, Kluttig A, Greiser H, Werdan K, Burkhardt K, Völzke H.
  Thyroid. 2014 Mar;24(3):424-32. doi: 10.1089/thy.2013.0259. Epub 2013 Nov 14. [PMID: 24102572]
  
• Research resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses.
  Kreuchwig A, Kleinau G, Krause G.
  Mol Endocrinol. 2013 Aug;27(8):1357-63. doi: 10.1210/me.2013-1115. Epub 2013 Jun 24. [PMID:23798574]
  
• Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies.
  Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, Köhrle J, Wiersinga WM.
  Clin Endocrinol (Oxf). 2014 Mar;80(3):444-51. doi: 10.1111/cen.12284. Epub 2013 Jul 31.
  
• The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
  Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.
  Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. [PMID: 23744028]
  
• Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.
  Piechowski CL, Rediger A, Lagemann C, Mühlhaus J, Müller A, Pratzka J, Tarnow P, Grüters A, Krude H, Kleinau G, Biebermann H.
  Journal of molecular endocrinology 51:109-118. Accepted Preprint (first posted online 14 May 2013)
  
• Novel insights on thyroid-stimulating hormone receptor signal transduction.
  Kleinau G, Neumann S, Grüters A, Krude H, Biebermann H.
  Endocr Rev. 2013 Oct;34(5):691-724. doi: 10.1210/er.2012-1072. [PMID: 23645907]
  
• Histidines in Potential Substrate Recognition Sites Affect Thyroid Hormone Transport by Monocarboxylate Transporter 8 (MCT8).
  Braun D, Lelios I, Krause G, Schweizer U.
  Endocrinology. 2013 Jul;154(7):2553-61. doi: 10.1210/en.2012-2197. Epub 2013 Apr 16. [PMID: 23592749]
  
• Thyroid Hormone, Thyroid Hormone Receptors, and Cancer: A Clinical Perspective
  Moeller LC, Führer D.
  Endocr Relat Cancer. 2013;20(2):R19–R29.
  
• Determinants Involved in Subtype-specific Functions of Rat Trace Amine-associated Receptors 1 and 4.
  Stäubert C, Bohnekamp J, Schöneberg T.
  Br J Pharmacol. 2013 Mar;168(5):1266-78. doi:10.1111/bph.12020. [PMID:23072560]
  
• Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.
  Hoyer I, Haas AK, Kreuchwig A, Schülein R, Krause G.
  Biochem Soc Trans. 2013 Feb 1;41(1):213-7.doi:0.1042/BST20120319. [PMID:23356285], [PMCID:PMC3561627]
  
• Molecules important for thyroid hormone synthesis and action - known facts and future perspectives
  Brix K, Führer D, Biebermann H.
  Thyroid Res. 2011; 4(Suppl 1): S9. Published online 2011 Aug 3. doi: 10.1186/1756-6614-4-S1-S9