Priority Programme: THYROID TRANS ACT
Translation of Thyroid Hormone Actions beyond Classical Concepts

Publications

• The colorful diversity of thyroid hormone metabolites.
  Köhrle J.
  European Thyroid Journal, 2019, in press. ETJ Lecture Award 2017
  
• Thyroid Hormone Metabolism
  Köhrle J.
  Ilpo Huhtaniemi and Luciano Martini, (Eds.), Encyclopedia of Endocrine Diseases, Second Edition, 2019, vol. 4, pp. 420–428.
  
• 3-Iodothyronamine-A Thyroid Hormone Metabolite With Distinct Target Profiles and Mode of Action.
  Köhrle J, Biebermann H.
  Endocr Rev. 2019 Apr 1;40(2):602-630. doi: 10.1210/er.2018-00182.
  
• Association Between 3-Iodothyronamine (T1am) Concentrations and Left Ventricular Function in Chronic Heart Failure.
  la Cour JL, Christensen HM, Köhrle J, Lehmphul I, Kistorp C, Nygaard B, Faber J.
  J Clin Endocrinol Metab. 2019 Apr 1;104(4):1232-1238. doi: 10.1210/jc.2018-01466.
  
• Circulating Adipokine VASPIN Is Associated with Serum Lipid Profiles in Humans.
  Breitfeld J, Wiele N, Gutsmann B, Stumvoll M, Blüher M, Scholz M, Kovacs P, Tönjes A.
  Lipids. 2019 Apr;54(4):203-210. doi: 10.1002/lipd.12139. Epub 2019 Mar 18.
  
• The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats.
  Šošić-Jurjević B, Lütjohann D, Renko K, Filipovic B, Ajdzanovic V, Trifunovic S, Nestorovic N, Zivanovic J, Manojlović-Stojanoski M, Köhrle J, Milosevic V.
  J Steroid Biochem Mol Biol. 2019 Mar 15;190:1-10. doi: 10.1016/j.jsbmb.2019.03.009. [Epub ahead of print]
  
• The Role of Dickkopf-1 in Thyroid Hormone-Induced Changes of Bone Remodeling in Male Mice.
  Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC, Rauner M.
  Endocrinology. 2019 Mar 1;160(3):664-674. doi: 10.1210/en.2018-00998.
  
• Thyroxine promotes lung cancer growth in an orthotopic mouse model.
  Latteyer S, Christoph S, Theurer S, Hönes GS, Schmid KW, Fuehrer D, Moeller LC.
  Endocr Relat Cancer. 2019 Mar 1. pii: ERC-18-0353.R1. doi: 10.1530/ERC-18-0353. [Epub ahead of print] PMID: 30893642
  
• Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organs
  Engels, K, Rakov H, Hönes GS, Brix K, Köhrle J, Zwanziger D, Moeller LC, Führer D.
  J Gerontol A Biol Sci Med Sci. 2019 Feb 16. pii: glz040. doi: 10.1093/gerona/glz040. [Epub ahead of print]
  
• Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis.
  Krause C, Grohs M, El Gammal A, Wolter S, Lehnert H, Mann O, Mittag J, Kirchner H.
  Endocr Connect. 2018 Nov 1. pii: EC-18-0499. doi: 10.1530/EC-18-0499. [Epub ahead of print]
  
• Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.
  Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE, Geelhoed B, Guo X, Kleber ME, Lin HJ, Lin H, MacFarlane P, Selvin E, Shaffer C, Smith AV, Verweij N, Weiss S, Cappola AR, Dörr M, Gudnason V, Heckbert S, Mooijaart S, März W, Psaty BM, Ridker PM, Roden D, Stott DJ, Völzke H, Benjamin EJ, Delgado G, Ellinor P, Homuth G, Köttgen A, Jukema JW, Lubitz SA, Mora S, Rienstra M, Rotter JI, Shoemaker MB, Sotoodehnia N, Taylor KD, van der Harst P, Albert CM, Chasman DI.
  JAMA Cardiol. 2019 Jan 23. doi: 10.1001/jamacardio.2018.4635. [Epub ahead of print]
  
• Aortic Effects of Thyroid Hormone in Male Mice.
  Gachkar S, Nock S, Geissler C, Ölkrug R, Johann K, Resch J, Rahman A, Arner A, Kirchner H, Mittag J.
  J Mol Endocrinol. 2019 Jan 1. pii: JME-18-0217.R1. doi: 10.1530/JME-18-0217. [Epub ahead of print]
  
• The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women.
  Sathyapalan T, Köhrle J, Rijntjes E, Rigby AS, Dargham SR, Kilpatrick ES, Atkin SL.
  Front Endocrinol (Lausanne). 2018 Nov 22;9:698. doi: 10.3389/fendo.2018.00698. eCollection 2018.
  
• Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes.
  Türker E, Garreis F, Khajavi N, Reinach PS, Joshi P, Brockmann T, Lucius A, Ljubojevic N, Turan E, Cooper D, Schick F, Reinholz R, Pleyer U, Köhrle J, Mergler S.
  Front Endocrinol (Lausanne). 2018 Nov 22;9:670. doi: 10.3389/fendo.2018.00670. eCollection 2018.
  
• TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells.
  Walcher L, Budde C, Böhm A, Reinach P, Dhandapani P, Ljubojevic N, Schweiger M, von der Waydbrink H, Reimers I, Köhrle J, Mergler S.
  Front Pharmacol. 2018 Nov 13;9:1234. doi: 10.3389/fphar.2018.01234. eCollection 2018.
  
• Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
  Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, Schultheiss UT, Traglia M, Ahluwalia TS, Akiyama M, Appel EVR, Arking DE, Arnold A, Astrup A, Beekman M, Beilby JP, Bekaert S, Boerwinkle E, Brown SJ, De Buyzere M, Campbell PJ, Ceresini G, Cerqueira C, Cucca F, Deary IJ, Deelen J, Eckardt KU, Ekici AB, Eriksson JG, Ferrrucci L, Fiers T, Fiorillo E, Ford I, Fox CS, Fuchsberger C, Galesloot TE, Gieger C, Gögele M, De Grandi A, Grarup N, Greiser KH, Haljas K, Hansen T, Harris SE, van Heemst D, den Heijer M, Hicks AA, den Hollander W, Homuth G, Hui J, Ikram MA, Ittermann T, Jensen RA, Jing J, Jukema JW, Kajantie E, Kamatani Y, Kasbohm E, Kaufman JM, Kiemeney LA, Kloppenburg M, Kronenberg F, Kubo M, Lahti J, Lapauw B, Li S, Liewald DCM; Lifelines Cohort Study, Lim EM, Linneberg A, Marina M, Mascalzoni D, Matsuda K, Medenwald D, Meisinger C, Meulenbelt I, De Meyer T, Meyer Zu Schwabedissen HE, Mikolajczyk R, Moed M, Netea-Maier RT, Nolte IM, Okada Y, Pala M, Pattaro C, Pedersen O, Petersmann A, Porcu E, Postmus I, Pramstaller PP, Psaty BM, Ramos YFM, Rawal R, Redmond P, Richards JB, Rietzschel ER, Rivadeneira F, Roef G, Rotter JI, Sala CF, Schlessinger D, Selvin E, Slagboom PE, Soranzo N, Sørensen TIA, Spector TD, Starr JM, Stott DJ, Taes Y, Taliun D, Tanaka T, Thuesen B, Tiller D, Toniolo D, Uitterlinden AG, Visser WE, Walsh JP, Wilson SG, Wolffenbuttel BHR, Yang Q, Zheng HF, Cappola A, Peeters RP, Naitza S, Völzke H, Sanna S, Köttgen A, Visser TJ, Medici M.
  Nat Commun. 2018 Oct 26;9(1):4455. doi: 10.1038/s41467-018-06356-1.
  
• Circulating Pro-Neurotensin in gestational diabetes mellitus.
  Tönjes A, Kralisch S, Hoffmann A, Schleinitz D, Kratzsch J, Blüher M, Stumvoll M, Kovacs P, Fasshauer M, Ebert T.
  Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):23-29. doi: 10.1016/j.numecd.2018.09.011. Epub 2018 Oct 20.
  
• 3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines.
  Bräunig J, Mergler S, Jyrch S, Hoefig CS, Rosowski M, Mittag J, Biebermann H, Khajavi N.
  Front Endocrinol (Lausanne). 2018 Sep 11;9:523. doi: 10.3389/fendo.2018.00523. eCollection 2018.
  
• The affinity of antipsychotic drugs to dopamine and serotonin 5-HT2 receptors determines their effects on prefrontal-striatal functional connectivity.
  Tollens F, Gass N, Becker R, Schwarz AJ, Risterucci C, Künnecke B, Lebhardt P, Reinwald J, Sack M, Weber-Fahr W, Meyer-Lindenberg A, Sartorius A.
  Eur Neuropsychopharmacol. 2018 Sep;28(9):1035-1046. doi: 10.1016/j.euroneuro.2018.05.016. Epub 2018 Jul 10.
  
• [Impact of thyroid diseases on bone].
  Tsourdi E, Lademann F, Siggelkow H.
  Internist (Berl). 2018 Jul;59(7):661-667. doi: 10.1007/s00108-018-0436-z.
  
• Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets.
  Köhrle J.
  Methods Mol Biol. 2018;1801:85-104. doi: 10.1007/978-1-4939-7902-8_9.
  
• Empowering thyroid hormone research in human subjects using OMICs technologies.
  Pietzner M, Kacprowski T, Friedrich N.
  J Endocrinol. 2018 Jul;238(1):R13-R29. doi: 10.1530/JOE-18-0117. Epub 2018 May 3.
  
• Comprehensive Metabolic Profiling Reveals a Lipid-Rich Fingerprint of Free Thyroxine Far Beyond Classic Parameters.
  Lange T, Budde K, Homuth G, Kastenmüller G, Artati A, Krumsiek J, Völzke H, Adamski J, Petersmann A, Völker U, Nauck M, Friedrich N, Pietzner M.
  J Clin Endocrinol Metab. 2018 May 1;103(5):2050-2060. doi: 10.1210/jc.2018-00183.
  
• Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)
  Sharlin DS, Ng L, Verrey F, Visser TJ, Liu Y, Olszewski RT, Hoa M, Heuer H, Forrest D.
  Scientific Reports, volume 8, Article number: 4403 (2018) doi:10.1038/s41598-018-22553-w
  
• Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration
  Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H, von Maltzahn J.
  Stem Cell Reports (2018), https://doi.org/10.1016/j.stemcr.2018.03.021
  
• Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.
  Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.
  J Neuroendocrinol. 2018 Mar;30(3):e12573. doi: 10.1111/jne.12573.
  
• Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression.
  Clemm von Hohenberg C, Weber-Fahr W, Lebhardt P, Ravi N, Braun U, Gass N, Becker R, Sack M, Cosa Linan A, Gerchen MF, Reinwald JR, Oettl LL, Meyer-Lindenberg A, Vollmayr B, Kelsch W, Sartorius A.
  Transl Psychiatry. 2018 Mar 27;8(1):68. doi: 10.1038/s41398-018-0121-y.
  
• Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression.
  Qatato M, Szumska J, Skripnik V, Rijntjes E, Köhrle J, Brix K.
  Front Pharmacol. 2018 Mar 20;9:221. doi: 10.3389/fphar.2018.00221. eCollection 2018.
  
• Effects of sildenafil treatment on thermogenesis and glucose homeostasis in diet-induced obese mice.
  Johann K, Reis MC, Harder L, Herrmann B, Gachkar S, Mittag J, Oelkrug R.
  Nutr Diabetes. 2018 Mar 13;8(1):9. doi: 10.1038/s41387-018-0026-0.
  
• The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor.
  Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H.
  Front Pharmacol. 2018 Mar 12;9:222. doi: 10.3389/fphar.2018.00222. eCollection 2018.
  
• Relationship Between 12 Adipocytokines and Distinct Components of the Metabolic Syndrome.
  Ebert T, Gebhardt C, Scholz M, Wohland T, Schleinitz D, Fasshauer M, Blüher M, Stumvoll M, Kovacs P, Tönjes A.
  J Clin Endocrinol Metab. 2018 Mar 1;103(3):1015-1023. doi: 10.1210/jc.2017-02085.
  
• Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.
  Tönjes A, Scholz M, Krüger J, Krause K, Schleinitz D, Kirsten H, Gebhardt C, Marzi C, Grallert H, Ladenvall C, Heyne H, Laurila E, Kriebel J, Meisinger C, Rathmann W, Gieger C, Groop L, Prokopenko I, Isomaa B, Beutner F, Kratzsch J, Fischer-Rosinsky A, Pfeiffer A, Krohn K, Spranger J, Thiery J, Blüher M, Stumvoll M, Kovacs P.
  Hum Mol Genet. 2018 Feb 1;27(3):546-558. doi: 10.1093/hmg/ddx413.
  
• In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice.
  Harder L, Schanze N, Sarsenbayeva A, Kugel F, Köhrle J, Schomburg L, Mittag J, Hoefig CS.
  Eur Thyroid J. 2018 Jan;7(1):3-12. doi: 10.1159/000481856. Epub 2017 Dec 5.
  
• Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
  Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC.
  Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11323-E11332. doi: 10.1073/pnas.1706801115. Epub 2017 Dec 11. PMID: 29229863.
  
• 3-Iodothyronamine reduces insulin secretion in vitro via a mitochondrial mechanism.
  Lehmphul I, Hoefig CS, Köhrle J.
  Mol Cell Endocrinol. 2018 Jan 15;460:219-228. doi: 10.1016/j.mce.2017.07.026. Epub 2017 Jul 25.
  
• A century of thyroid hormone research - Vol. II : Evolution and Development of the Thyroid System
  Edited by Robert Opitz and Josef Köhrle
  Molecular and Cellular Endocrinology, Volume 459, Pages 1-116 (25 December 2017).
  
• A century of thyroid hormone research - Vol. I: The expanded thyroid hormone network: novel metabolites and modes of action
  Edited by Josef Köhrle and Carolin S. Höfig
  Molecular and Cellular Endocrinology, Volume 458, Pages 1-168 (15 December 2017).
  
• Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.
  Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H.
  Cell Mol Life Sci. 2018 Jun;75(12):2227-2239. doi: 10.1007/s00018-017-2728-1. Epub 2017 Dec 30.
  
• Neural Mechanisms of Early-Life Social Stress as a Developmental Risk Factor for Severe Psychiatric Disorders.
  Reinwald JR, Becker R, Mallien AS, Falfan-Melgoza C, Sack M, Clemm von Hohenberg C, Braun U, Cosa Linan A, Gass N, Vasilescu AN, Tollens F, Lebhardt P, Pfeiffer N, Inta D, Meyer-Lindenberg A, Gass P, Sartorius A, Weber-Fahr W.
  Biol Psychiatry. 2018 Jul 15;84(2):116-128. doi: 10.1016/j.biopsych.2017.12.010. Epub 2017 Dec 28.
  
• Editorial: Get inspired - Lessons learned from evolution of thyroid hormone signaling in developmental processes.
  Opitz R, Köhrle J.
  Molecular and Cellular Endocrinology 459 (2017) Volume 459, 25 December 2017, 1-4
  
• Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice
  Rakov H, Engels K, Hönes GS, Brix K, Köhrle J, Moeller LC, Zwanziger D, FührerD.
  Biol Sex Differ. 2017; 8: 38. Published online 2017 Dec 22. doi: 10.1186/s13293-017-0159-1
  
• Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.
  Popławski P, Wiśniewski JR, Rijntjes E, Richards K, Rybicka B, Köhrle J, Piekiełko-Witkowska A.
  PLoS One. 2017 Dec 22;12(12):e0190179. doi: 10.1371/journal.pone.0190179. eCollection 2017.
  
• T-Time again - The diversity of actions of thyroid hormones (TH), their aminergic (TAM) and acetic acid (TAc) metabolites.
  Höfig CS, Köhrle J.
  Mol Cell Endocrinol. 2017 Dec 15;458:1-5. doi: 10.1016/j.mce.2017.10.007.
  
• Thyroid hormones and browning of adipose tissue.
  Weiner J, Hankir M, Heiker JT, Fenske W, Krause K.
  Mol Cell Endocrinol. 2017 Dec 15;458:156-159. doi: 10.1016/j.mce.2017.01.011. Epub 2017 Jan 12.
  
• Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1.
  Mühlhaus J, Dinter J, Jyrch S, Teumer A, Jacobi SF, Homuth G, Kühnen P, Wiegand S, Grüters A, Völzke H, Raile K, Kleinau G, Krude H, Biebermann H.
  Front Pharmacol. 2017 Nov 24;8:807. doi: 10.3389/fphar.2017.00807. eCollection 2017.
  
• Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events: Result of the HNR Study (Heinz Nixdorf Recall).
  Lehmann N, Erbel R, Mahabadi AA, Rauwolf M, Möhlenkamp S, Moebus S, Kälsch H, Budde T, Schmermund A, Stang A, Führer-Sakel D, Weimar C, Roggenbuck U, Dragano N, Jöckel KH; Heinz Nixdorf Recall Study Investigators.
  Circulation. 2018 Feb 13;137(7):665-679. doi: 10.1161/CIRCULATIONAHA.116.027034. Epub 2017 Nov 15.
  
• Sclerostin Blockade and Zoledronic Acid Improve Bone Mass and Strength in Male Mice With Exogenous Hyperthyroidism.
  Tsourdi E, Lademann F, Ominsky MS, Rijntjes E, Köhrle J, Misof BM, Roschger P, Klaushofer K, Hofbauer LC, Rauner M.
  Endocrinology. 2017 Nov 1;158(11):3765-3777. doi: 10.1210/en.2017-00247.
  
• Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.
  Zieger K, Weiner J, Kunath A, Gericke M, Krause K, Kern M, Stumvoll M, Klöting N, Blüher M, Heiker JT.
  Cell Mol Life Sci. 2017 Sep 20. doi: 10.1007/s00018-017-2658-y. [Epub ahead of print]. PMID:28932870.
  
• 3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?
  Khajavi N, Mergler S, Biebermann H.
  Front Endocrinol (Lausanne). 2017 Aug 16;8:198. doi: 10.3389/fendo.2017.00198. eCollection 2017.
  
• Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
  Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M.
  Nature Communications 8, Article number: 484 (2017). doi:10.1038/s41467-017-00604-6
  
• A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes.
  Richards KH, Schanze N, Monk R, Rijntjes E, Rathmann D, Köhrle J.
  PLoS One. 2017 Aug 24;12(8):e0183482. doi: 10.1371/journal.pone.0183482. eCollection 2017.
  
• Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy
  Oelkrug R, Herrmann B, Geissler C, Harder L, Koch C, Lehnert H, Oster H, Kirchner H, Mittag J.
  Molecular Metabolism 2017, DOI: http://dx.doi.org/10.1016/j.molmet.2017.06.016
  
• Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway.
  Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, Blüher M, Heiker JT.
  Mol Cell Endocrinol. 2017 Jul 26. pii: S0303-7207(17)30395-7. doi: 10.1016/j.mce.2017.07.022. [Epub ahead of print]
  
• Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
  Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M; all members of the PanEuropean Working group on ACP.
  Gut. 2018 Oct;67(10):1855-1863. doi: 10.1136/gutjnl-2017-314454. Epub 2017 Jul 28.
  
• Differential Regulation of Monocarboxylate Transporter 8 Expression in Thyroid Cancer and Hyperthyroidism.
  Badziong J, Ting S, Synoracki S, Tiedje V, Brix K, Brabant G, Moeller LC, Schmid KW, Führer-Sakel D, Zwanziger D.
  Eur J Endocrinol. 2017 Jun 2. pii: EJE-17-0279. doi: 10.1530/EJE-17-0279. [Epub ahead of print] PMID:28576880
  
• Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.
  Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley RA, Gygi SP, Stoedter M, Wisniewska M, Köhrle J, Gladyshev VN, Schomburg L.
  Sci Rep. 2017 Jun 29;7(1):4391. doi: 10.1038/s41598-017-04586-9. PMID:28663583.
  
• Membrane traversing mechanism for thyroid hormone transport at MCT8
  Protze J, Braun D, Hinz KM, Bayer-Kusch D, Schweizer U, Krause G.
  Cell Mol Life Sci, 2017 Jun;74(12):2299-2318. doi: 10.1007/s00018-017-2461-9. Epub 2017 Jan 28
  
• Spurenelemente und Mineralstoffe
  Köhrle J, Schomburg L, Schümann K.
  Biesalski et al. 2017, Ernährungmedizin, 5. Auflage, Thieme Verlag, Stuttgart. Kap. 11, pp.199-223.
  
• Iodstoffwechsel und Schilddrüsenkrankheiten
  Köhrle J.
  Biesalski et al. 2017, Ernährungmedizin, 5. Auflage, Thieme Verlag, Stuttgart. Kap. 71, 980-990.
  
• Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
  Graff M, Scott RA, Justice AE, Young KL, et al.
  PLoS Genet. 2017 Apr 27;13(4):e1006528. doi: 10.1371/journal.pgen.1006528. eCollection 2017 Apr.
  
• Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.
  Kleinau G, Worth CL, Kreuchwig A, Biebermann H, Marcinkowski P, Scheerer P, Krause G.
  Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017.
  
• TRH action is impaired in pituitaries of male IGSF1-deficient mice
  Turgeon M-O, Silander TL, Doycheva D, Liao X-H, Rigden M, Ongaro L, Zhou X, Joustra SD, Wit JM, Wade MG, Heuer H, Refetoff S, Bernard DJ.
  Endocrinology, Endocrine Society, Submitted: October 24, 2016 Accepted: January 06, 2017, First Online: January 13, 2017. DOI: 10.1210/en.2016-1788
  
• Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation.
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  Eur Thyroid J. 2015 Sep; 4(Suppl 1): 42–50. Published online 2015 May 28. doi: 10.1159/000381542. PMCID: PMC4640293
  
• Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth.
  Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H.
  J Clin Endocrinol Metab. 2015 May;100(5):2090-7. doi: 10.1210/jc.2014-4466. Epub 2015 Mar 17. PMID: 25781359 [PubMed - indexed for MEDLINE]
  
• 3-iodothyronamine differentially modulates alpha-2A adrenergic receptor-mediated signaling.
  Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Höfig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.
  J Mol Endocrinol. 2015 Apr 15. pii: JME-15-0003. [Epub ahead of print] PMID: 25878061
  
• Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls.
  Ebert T, Kralisch S, Wurst U, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Tönjes A, Fasshauer M.
  Eur J Endocrinol. 2015 Jul;173(1):1-7. doi: 10.1530/EJE-14-0815. Epub 2015 Apr 7.
  
• Indications for potential parent-of-origin effects within the FTO gene.
  Liu X, Hinney A, Scholz M, Scherag A, Tönjes A, Stumvoll M, Stadler PF, Hebebrand J, Böttcher Y.
  PLoS One. 2015 Mar 20;10(3):e0119206. doi: 10.1371/journal.pone.0119206. eCollection 2015.
  
• Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
  Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H.
  PLoS One. 2015 Feb 23;10(2):e0117774. doi: 10.1371/journal.pone.0117774. eCollection 2015.
  
• Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds.
  Stoedter M, Renko K, Ibáñez E, Plano D, Becker NP, Martitz J, Palop JA, Calvo A, Sanmartín C, Schomburg L.
  Metallomics. 2015 Feb 11;7(2):347-54. doi: 10.1039/c4mt00273c.PMID: 25579002[PubMed - in process]
  
• Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.
  Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.
  J Mol Endocrinol. 2015 Feb;54(1):39-50. doi: 10.1530/JME-14-0272. PMID: 25527620
  
• Absence of TRH-receptor 1 in male mice affects gastric ghrelin production
  Mayerl S, Liebsch C, Visser TJ, Heuer H.
  Endocrinology. doi: 10.1210/en.2014-1395. Received: May 15, 2014. Accepted: December 04, 2014. Published Online: December 09, 2014
  
• Circulating angiopoietin-like protein 8 is independently associated with fasting plasma glucose and type 2 diabetes mellitus.
  Ebert T1, Kralisch S, Hoffmann A, Bachmann A, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Tönjes A, Fasshauer M.
  J Clin Endocrinol Metab. 2014 Dec;99(12):E2510-7. doi: 10.1210/jc.2013-4349.
  
• Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells
  Khajavi N, Reinach PS, Slavi N, Skrzypski M, Lucius A, Strauß O, Köhrle J, Mergler S.
  Cellular Signalling, Volume 27, Issue 2, February 2015, Pages 315–325. doi:10.1016/j.cellsig.2014.11.015. Received: 16 September 2014. Received in revised form: 31 October 2014. Accepted: 12 November 2014. Available online: 21 November 2014
  
• [SPP-related publication] In Vitro and Mouse Studies Supporting Therapeutic Utility of Triiodothyroacetic Acid in MCT8 Deficiency.
  Kersseboom S, Horn S, Visser WE, Chen J, Friesema EC, Vaurs-Barrière C, Peeters RP, Heuer H, Visser TJ.
  Mol Endocrinol. 2014 Nov 12:me20141135. [Epub ahead of print] doi: 10.1210/me.2014-1135
  
• Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile
  Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Chun-Xia Yi, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H.
  Int. J. Mol. Sci. 2014, 15, 20638-20655. doi:10.3390/ijms151120638. Received: 3 August 2014; in revised form: 25 October 2014. Accepted: 4 November 2014. Published: 10 November 2014
  
• Translating pharmacological findings from hypothyroid rodents to euthyroid humans: Is there a functional role of endogenous 3,5-T2?
  Pietzner M, Lehmphul I, Friedrich N, Schurmann C, Ittermann T, Dörr M, Nauck M, Laqua R, Völker U, Brabant G, Völzke H, Koehrle J, Homuth G, Wallaschofski H.
  doi:10.1089/thy.2014.0262 Thyroid. 2014 Oct 24. [Epub ahead of print]
  
• 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male dietinduced obese mice.
  Jonas W, Lietzow J, Wohlgemuth F, Hoefig CS, Wiedmer P, Schweizer U, Köhrle J, Schürmann A.
  Endocrinology. 2014 Oct 16:en20141604. [Epub ahead of print] PMID:25322465
  
• High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population.
  Ittermann T, Dörr M, Völzke H, Tost F, Lehmphul I, Köhrle J, Jürgens C.
  Thyroid. 2014 Oct;24(10):1473-8. doi: 10.1089/thy.2014.0190. PMID:25156414 [PubMed - in process]
  
• Constitutive activities in the thyrotropin receptor: regulation and significance
  Kleinau G, Biebermann H.
  Adv Pharmacol. 2014;70:81-119. doi:10.1016/B978-0-12-417197-8.00003-1. PMID:24931193 [PubMed - in process]
  
• Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets.
  Spitzweg C, Bible KC, Hofbauer LC, Morris JC.
  Lancet Diabetes Endocrinol. 2014 Oct;2(10):830-42. doi: 10.1016/S2213-8587(14)70051-8. Epub 2014 Jun 2. PMID:24898835 [PubMed - in process]
  
• Structure and Function of Thyroid Hormone Plasma Membrane Transporters
  Schweizer U, Johannes J, Bayer D, Braun D.
  Published online: September 10, 2014, Eur Thyroid J 2014;3:143-153. doi:10.1159/000367858
  
• Serum thyroid-stimulating hormone levels are not associated with exercise capacity and lung function parameters in two population-based studies.
  Ittermann T, Gläser S, Ewert R, Felix S, Völzke H, Dörr M.
  BMC Pulm Med. 2014 Sep 2;14:145. doi: 10.1186/1471-2466-14-145. PMID:25182209 [PubMed - in process]
  
• Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody-based chemiluminescence immunoassay.
  Lehmphul I, Brabant G, Wallaschofski H, Ruchala M, Strasburger CJ, Köhrle J, Wu Z.
  Thyroid. 2014 Sep;24(9):1350-60. doi: 10.1089/thy.2013.0688. Epub 2014 Aug 1. PMID:24967815
  
• Progression of coronary artery calcification seems to be inevitable, but predictable - results of the Heinz Nixdorf Recall (HNR) study.
  Erbel R, Lehmann N, Churzidse S, Rauwolf M, Mahabadi AA, Möhlenkamp S, Moebus S, Bauer M, Kälsch H, Budde T, Montag M, Schmermund A, Stang A, Führer-Sakel D, Weimar C, Roggenbuck U, Dragano N, Jöckel KH; Heinz Nixdorf Recall Study Investigators.
  Eur Heart J. 2014 Nov 7;35(42):2960-71. doi: 10.1093/eurheartj/ehu288. Epub 2014 Jul 25.
  
• Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.
  Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE.
  Int J Cancer. 2015 Mar 1;136(5):1149-61. doi: 10.1002/ijc.29071. Epub 2014 Jul 21.
  
• Transport of thyroid hormone in brain.
  Wirth EK, Schweizer U, Köhrle J.
  Front Endocrinol (Lausanne). 2014 Jun 24;5:98. doi: 10.3389/fendo.2014.00098. eCollection 2014. Review. PMID:25009532 [PubMed]
  
• Expression pattern of thyroid hormone transporters in the postnatal mouse brain
  Müller J, Heuer H.
  Front. Endocrinol., 18 June 2014 | doi: 10.3389/fendo.2014.00092
  
• [SPP-related publication] - Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
  Schweizer U, Schlicker C, Braun D, Köhrle J, Steegbornd C.
  Published online before print July 7, 2014, doi:10.1073/pnas.1323873111 PNAS July 7, 2014
  
• Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors.
  Illouz F, Braun D, Briet C, Schweizer U, Rodien P.
  Eur J Endocrinol. 2014 Sep;171(3):R91-9. doi: 10.1530/EJE-14-0198. Epub 2014 May 15. Review.
  
• Selenoprotein P is the essential selenium transporter for bones.
  Pietschmann N, Rijntjes E, Hoeg A, Stoedter M, Schweizer U, Seemann P, Schomburg L.
  Metallomics. 2014 May;6(5):1043-9. doi: 10.1039/c4mt00003j.PMID: 24626785 [PubMed - indexed for MEDLINE]
  
• Hypoxia reduces and redirects selenoprotein biosynthesis.
  Becker NP, Martitz J, Renko K, Stoedter M, Hybsier S, Cramer T, Schomburg L.
  Metallomics. 2014 May;6(5):1079-86. doi: 10.1039/c4mt00004h. PMID: 24700164 [PubMed - indexed for MEDLINE]
  
• Soy isoflavones interfere with thyroid hormone homeostasis in orchidectomized middle-aged rats.
  Šošić-Jurjević B, Filipović B, Wirth EK, Živanović J, Radulović N, Janković S, Milošević V, Köhrle J.
  Toxicol Appl Pharmacol. 2014 Jul 15;278(2):124-34. doi: 10.1016/j.taap.2014.04.018. Epub 2014 Apr 29.
  
• Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
  Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H.
  J Clin Invest. 2014 May 1;124(5):1987-99. Epub 2014 Apr 1. [PMID:24691440]
  
• [Thyroid hormone action beyond classical concepts. The priority programme "Thyroid Trans Act" (SPP 1629) of the German Research Foundation]
  Führer D, Brix K, Biebermann H.
  Dtsch Med Wochenschr. 2014 Mar;139(10):492-6. doi: 10.1055/s-0034-1369822. Epub 2014 Feb 25. Review. German.
  
• Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
  Medici M, Porcu E, Pistis G, Teumer A, Brown SJ, Jensen RA, Rawal R, Roef GL, Plantinga TS, Vermeulen SH, Lahti J, Simmonds MJ, Husemoen LL, Freathy RM, Shields BM, Pietzner D, Nagy R, Broer L, Chaker L, Korevaar TI, Plia MG, Sala C, Völker U, Richards JB, Sweep FC, Gieger C, Corre T, Kajantie E, Thuesen B, Taes YE, Visser WE, Hattersley AT, Kratzsch J, Hamilton A, Li W, Homuth G, Lobina M, Mariotti S, Soranzo N, Cocca M, Nauck M, Spielhagen C, Ross A, Arnold A, van de Bunt M, Liyanarachchi S, Heier M, Grabe HJ, Masciullo C, Galesloot TE, Lim EM, Reischl E, Leedman PJ, Lai S, Delitala A, Bremner AP, Philips DI, Beilby JP, Mulas A, Vocale M, Abecasis G, Forsen T, James A, Widen E, Hui J, Prokisch H, Rietzschel EE, Palotie A, Feddema P, Fletcher SJ, Schramm K, Rotter JI, Kluttig A, Radke D, Traglia M, Surdulescu GL, He H, Franklyn JA, Tiller D, Vaidya B, de Meyer T, Jørgensen T, Eriksson JG, O'Leary PC, Wichmann E, Hermus AR, Psaty BM, Ittermann T, Hofman A, Bosi E, Schlessinger D, Wallaschofski H, Pirastu N, Aulchenko YS, de la Chapelle A, Netea-Maier RT, Gough SC, Meyer Zu Schwabedissen H, Frayling TM, Kaufman JM, Linneberg A, Räikkönen K, Smit JW, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Walsh JP, Meisinger C, den Heijer M, Visser TJ, Spector TD, Wilson SG, Völzke H, Cappola A, Toniolo D, Sanna S, Naitza S, Peeters RP.
  PLoS Genet. 2014 Feb 27;10(2):e1004123. doi: 10.1371/journal.pgen.1004123. eCollection 2014 Feb.
  
• Authentic Bosutinib Inhibits T3-Transport by Monocarboxylate Transporter 8 (MCT8).
  Braun D, Schweizer U.
  Thyroid. 2014 Jan 30. Epub ahead of print. [PMID:24479416]
  
• Tissue-Specific Alterations in Thyroid Hormone Homeostasis in Combined Mct10 and Mct8 Deficiency.
  Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H.
  Endocrinology. 2014 Jan;155(1):315-25. doi: 10.1210/en.2013-1800. Epub 2013 Dec 20. [PMID: 24248460]
  
• EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene.
  Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C.
  Mol Ther Nucleic Acids. 2013 Nov 5;2:e131. doi: 10.1038/mtna.2013.58. PMID:24193032 [PubMed] PMCID:PMC3889187
  
• Sex-specific associations between thyrotropin and serum lipid profiles.
  Meisinger C, Ittermann T, Tiller D, Agger C, Nauck M, Schipf S, Wallaschofski H, Jørgensen T, Linneberg A, Thiery J, Kluttig A, Greiser H, Werdan K, Burkhardt K, Völzke H.
  Thyroid. 2014 Mar;24(3):424-32. doi: 10.1089/thy.2013.0259. Epub 2013 Nov 14. [PMID: 24102572]
  
• Research resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses.
  Kreuchwig A, Kleinau G, Krause G.
  Mol Endocrinol. 2013 Aug;27(8):1357-63. doi: 10.1210/me.2013-1115. Epub 2013 Jun 24. [PMID:23798574]
  
• Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies.
  Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, Köhrle J, Wiersinga WM.
  Clin Endocrinol (Oxf). 2014 Mar;80(3):444-51. doi: 10.1111/cen.12284. Epub 2013 Jul 31.
  
• The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
  Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.
  Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. [PMID: 23744028]
  
• Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.
  Piechowski CL, Rediger A, Lagemann C, Mühlhaus J, Müller A, Pratzka J, Tarnow P, Grüters A, Krude H, Kleinau G, Biebermann H.
  Journal of molecular endocrinology 51:109-118. Accepted Preprint (first posted online 14 May 2013)
  
• Novel insights on thyroid-stimulating hormone receptor signal transduction.
  Kleinau G, Neumann S, Grüters A, Krude H, Biebermann H.
  Endocr Rev. 2013 Oct;34(5):691-724. doi: 10.1210/er.2012-1072. [PMID: 23645907]
  
• Histidines in Potential Substrate Recognition Sites Affect Thyroid Hormone Transport by Monocarboxylate Transporter 8 (MCT8).
  Braun D, Lelios I, Krause G, Schweizer U.
  Endocrinology. 2013 Jul;154(7):2553-61. doi: 10.1210/en.2012-2197. Epub 2013 Apr 16. [PMID: 23592749]
  
• Determinants Involved in Subtype-specific Functions of Rat Trace Amine-associated Receptors 1 and 4.
  Stäubert C, Bohnekamp J, Schöneberg T.
  Br J Pharmacol. 2013 Mar;168(5):1266-78. doi:10.1111/bph.12020. [PMID:23072560]
  
• Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.
  Hoyer I, Haas AK, Kreuchwig A, Schülein R, Krause G.
  Biochem Soc Trans. 2013 Feb 1;41(1):213-7.doi:0.1042/BST20120319. [PMID:23356285], [PMCID:PMC3561627]
  
• Molecules important for thyroid hormone synthesis and action - known facts and future perspectives
  Brix K, Führer D, Biebermann H.
  Thyroid Res. 2011; 4(Suppl 1): S9. Published online 2011 Aug 3. doi: 10.1186/1756-6614-4-S1-S9