Priority Programme: THYROID TRANS ACT
Translation of Thyroid Hormone Actions beyond Classical Concepts

Prof. Dr. Thomas F. Münte, Prof. Dr. Georg Brabant

Consequences of short-term hypo- and hyperthyroidism on brain structure and function in humans

This project will provide a comprehensive picture of the effects of mild hypo- and hyperthyroidism on higher cognitive function, white and grey brain matter structure, brain functional connectivity and brain perfusion, by using state of the art multimodal neuroimaging and neurocognitive testing. Such a data base is necessary for the understanding of the scope of thyroid hormone action in the CNS. Mild hypothyroidism will be induced in a group of 20 athyroid participants by reducing L-Thyroxine to achieve a TSH-level of approximately 10-15 mU / liter. Imaging and cognitive testing will be performed prior to and after a period of 8 weeks of hypothyroidism. Mild hyperthyroidism will be induced in 20 healthy volunteers who will receive 250 µg of L-Thyroxine per day over 8 weeks. Again, imaging and cognitive testing will be performed prior to and after the treatment period. In a second part of the project, using an existing extensively phenotyped (cognitive functions, personality, imaging) cohort, we will assess the effects of genetic differences in thyroid hormone transporters (polymorphisms of MCT8 and possibly other transporter molecules) on the central availability of thyroid hormones indexed by cognitive function and brain structural measures. 

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Project Coordinator(s):

Prof. Dr. Thomas F. Münte
Universität zu Lübeck
Klinik für Neurologie und Medizinische Klinik
Ratzeburger Allee 160
23538 Lübeck
Phone: +49 451 500 2925
Fax: +49 451 500 5457
thomas.muente@neuro.uni-luebeck.de

Prof. Dr. Georg Brabant
Universität zu Lübeck
Klinik für Neurologie und Medizinische Klinik
Ratzeburger Allee 160
23538 Lübeck
Phone: +49 451 500 2925
Fax: +49 451 500 5457
georg.brabant@uksh.de