Priority Programme: THYROID TRANS ACT
Translation of Thyroid Hormone Actions beyond Classical Concepts

Dr. Claudia Stäubert, Prof. Dr. Torsten Schöneberg

Trace amine-associated receptors (TAAR) as targets for thyronamines

3-iodothyronamine (T1AM), an endogenous derivative and degradation product of thyroid hormones, exerts several biological functions, like reduction in body temperature, heart rate, and metabolism, and is an agonist at trace amine-associated receptor 1 (TAAR1). TAAR1 was first deorphanized as receptor activated by trace amines, namely β-phenylethylamine, p-tyramine and tryptamine, but also by psychoactive compounds like MDMA, amphetamine and LSD. TAAR1 is a Gαs protein-coupled receptor and a member of the TAAR family consisting of nine subtypes in mammals. We test the hypothesis that the entire TAAR subfamily may be activated by metabolites of thyroid hormones. Specifically, T1AM action at all TAAR family members, the evolutionary conservation of T1AM function at TAAR1, the molecular basis of ligand specificity and the functional relevance of TAAR redundancy are studied. Further, we investigate the concept of an exclusive intracellular (not plasma membrane bound) signaling as well as non-G protein-mediated signaling of T1AM. Our goal is to fundamentally extent our knowledge of the molecular mechanisms and consequences of T1AM action.

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Project Coordinator(s):

Dr. Claudia Stäubert
Universität Leipzig, Medizinische Fakultät
Institut für Biochemie
Johannisallee 30
04103 Leipzig
Phone: +49 341 9722 177
Fax: +49 341 9722 159
claudia_staeubert@gmx.de

Prof. Dr. Torsten Schöneberg
Universität Leipzig, Medizinische Fakultät
Institut für Biochemie
Johannisallee 30
04103 Leipzig
Phone: +49 341 9722 151 /-150
Fax: +49 341 9722 159
schoberg@medizin.uni-leipzig.de