Priority Programme: THYROID TRANS ACT
Translation of Thyroid Hormone Actions beyond Classical Concepts

Prof. Dr. Heike Biebermann

3-iodothyronamine induced signaling of Trace Amine-Associated Receptor subtypes and their role in neuromodulation

Recently, a new thyroid hormone derivative, 3`-iodotyronamine (T1AM) was detected. Application of T1AM in mice results in reduction of body temperature and heart frequency, effects that are in contrast to the known action of thyroid hormones. So far the physiological and pathophysiological role of thyronamines has been largely unknown. A possibility to clarify these aspects is the finding that T1AM activates a G protein-coupled receptor (GPCR), the trace amine associated receptor 1 (TAAR1). This receptor belongs to a class of recently identified trace amine-associated receptors (TAAR). TAAR1 is activated by a variety of ligands including serotonin and dopamine and is supposed to play a role in neuromodulation. Under this aspect, it is the aim of the applied project to investigate the extended signal transduction properties after T1AM challenge. We want to rule out whether other TAARs, especially TAAR5, are responsible for the observed T1AM effects. Due to the fact that protein-protein interactions are of increasing interest to understand the function of a GPCR we aim to identify interaction partners for TAAR1 and TAA5 with the purpose of a better understanding of T1AM mediated effects. Additionally, we aim to verify obtained results in a in vivo-like cell model of three dimensional neuronal neuropheres in which selective analysis of TAAR1 and TAAR5 is possible.

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Project Coordinator(s):

Prof. Dr. Heike Biebermann
Charité Universitätsmedizin Berlin
Institut für Experimentelle Pädiatrische Endokrinologie
Augustenburger Platz 1
13353 Berlin
Phone: +49 30 450 559 828
Fax: +49 30 450 559 941
Heike.Biebermann@charite.de